Results 141 to 150 of about 901,766 (310)
Advanced Science, EarlyView.ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu +12 more
wiley +1 more source
Metabolic adaptations to high-fat diet [PDF]
Nature Reviews Endocrinology, 2018 openaire +2 more sources
Advanced Science, EarlyView.The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan +16 more
wiley +1 more source
Ruminal bacterial community change in response to diet-induced variation of ruminal trans-10 fatty acids [PDF]
, 2011 Trans fatty acids (FA) are produced during the biohydrogenation of linoleic acid in the rumen. Because of their health‐promoting properties, trans‐11 isomers, which are usually the most abundant biohydrogenation intermediates, are most desirable (1 ...
Cauquil, Laurent +4 more
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Advanced Science, EarlyView.This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao +18 more
wiley +1 more source
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
An Analysis of the Consumption of Sausages in Scotland using Supermarket Data [PDF]
This paper addresses consumers’ choices by looking into: current food choices made by different socio-economic groups; price barriers for diet improvement; and ways in which marketing may affect product choice.
Davis, Victoria +5 more
core +4 more sources
, 1985 This review examines the relationship between dietary fat intake and health. ,Heal produced by modem farming methods has a high fat content in comparison with its natural counterpart and, furthermore, the fat is low in Polysaturated fat.
Temple, Norman J.
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Advanced Science, EarlyView.4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang +7 more
wiley +1 more source
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, EarlyView.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source