Results 31 to 40 of about 137,948 (168)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

L’accuratezza delle immagini Google Earth: un caso-studio sulla città di Pavia

GEOmedia, 2011
L’avvento di Google Earth ha certamente rivoluzionato il mondo dell’informazione geografica e ha creato di fatto un nuovo tipo di prodotto cartografico, i Digital Globe. Per la verità, esistevano esempi simili già in precedenza, ma è stato Google Earth a
Vittorio Casella, Marica Franzini, Barbara Padova   +2 more
doaj  

Atomistic insights into the magnetic-field modulation of the $$\hbox {A}_{2A}$$ adenosine receptor

Scientific Reports
Pulsed electromagnetic fields (PEMFs) are increasingly used in clinical settings for the treatment of inflammatory and degenerative conditions. Among their molecular targets, $$\hbox {A}_{2A}$$ adenosine receptors ( $$\hbox {A}_{2A}\hbox {ARs}$$ ) show ...
Carmen Pisano, Federico Del Signore, Paolo Marracino, Ilaria Pappa, Davide Cocco, Elena Della Valle, Simona Salati, Ruggero Cadossi, Micaela Liberti, Francesca Apollonio   +9 more
doaj   +1 more source

Verification of the electromagnetic deep-penetration effect in the real world

Scientific Reports, 2021
The deep penetration of electromagnetic waves into lossy media can be obtained by properly generating inhomogeneous waves. In this work, for the very first time, we demonstrate the physical implementation and the practical relevance of this phenomenon. A
Paolo Baccarelli, Alessandro Calcaterra, Fabrizio Frezza, Fabio Mangini, Nicholas Ricciardella, Patrizio Simeoni, Nicola Tedeschi   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A 0.15-to-0.5 V Body-Driven Dynamic Comparator with Rail-to-Rail ICMR

Journal of Low Power Electronics and Applications, 2023
In this paper, a novel dynamic body-driven ultra-low voltage (ULV) comparator is presented. The proposed topology takes advantage of the back-gate configuration by driving the input transistors’ gates with a clocked positive feedback loop made of two AND
Riccardo Della Sala, Valerio Spinogatti, Cristian Bocciarelli, Francesco Centurelli, Alessandro Trifiletti   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source