Results 41 to 50 of about 1,192,707 (264)
A RISC-V Fault-Tolerant Soft-Processor Based on Full/Partial Heterogeneous Dual-Core Protection
IEEE AccessThe low probability of single event upsets (SEU) within particular satellite orbits, makes Commercial-off-the-shelf (COTS) electronic components a viable solution for space system implementation, thanks to the introduction of design-level fault tolerance
Francesco Vigli +5 more
doaj +1 more source
A 0.3V Rail-to-Rail Three-Stage OTA With High DC Gain and Improved Robustness to PVT Variations
IEEE Access, 2023 This paper presents a novel 0.3V rail-to-rail body-driven three-stage operational transconductance amplifier (OTA). The proposed OTA architecture allows achieving high DC gain in spite of the bulk-driven input.
Riccardo Della Sala +4 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Healthy lifestyle and life expectancy with and without major chronic disease – a cohort study
Scientific ReportsHealth behaviors affect life expectancy, but whether disease is present can greatly impact both the individual and society. How health behavior is reflected in the utilization of health care services is yet to be investigated to support the impact of ...
Anne Kirstine Eriksen +5 more
doaj +1 more source
Immunological MedicineMetabolic syndromes including obesity and diabetes are the most common health issues due to insulin resistance, disturbance in glucose homeostasis, lack of exercise, and improper diet.
Asma Draz +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
BMC Medicine, 2021 Background Characteristics of the built environment, such as neighbourhood fast-food outlet exposure, are increasingly recognised as risk factors for unhealthy diet and obesity.
Thomas Burgoine +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Adaptive Data Synchronization Algorithm for IoT-Oriented Low-Power Wide-Area Networks
Sensors, 2018 The Internet of Things (IoT) is by now very close to be realized, leading the world towards a new technological era where people’s lives and habits will be definitively revolutionized.
Andrea Petroni +5 more
doaj +1 more source