Results 51 to 60 of about 317,123 (307)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Selective exposure shapes the Facebook news diet

PLOS ONE, 2020
PLOS One Published: March 13 ...
Cinelli, Matteo, Brugnoli, Emanuele, Schmidt, Ana Lucia, Zollo, Fabiana, Quattrociocchi, Walter, Scala, Antonio   +5 more
openaire   +6 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Intake and diet preference of dairy heifers grazing mixed or alternating rows of birdsfoot trefoil and cool‐season grasses

Grassland Research
Background Mixtures with birdsfoot trefoil (BFT) increase herbage intake in grazing cattle. We hypothesized that BFT spatially separated from grasses would increase preferential grazing of BFT and herbage intake compared to grass and BFT in mixed rows ...
Michael D. Peel, Blair L. Waldron, Jacob T. Briscoe, Marcus F. Rose, S. Clay Isom, Kara J. Thornton, Jacob A. Hadfield, Kerry A. Rood, J. Earl Creech   +8 more
doaj   +1 more source

Choice of grazed herbage or maize silage by lactating dairy cows: influence of sward height and concentrate level Preferência por pastagem ou silagem de milho por vacas leiteiras em lactação: influência da altura do pasto e do nível de concentrado

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2010
The preference of lactating dairy cows for grazed herbage or maize silage (MS), simultaneously offered ad libitum in the field, was examined at two sward heights (SH 4-6 and 8-10cm) and two concentrate levels (CL 0 and 6kg day-1) in a 2x2 factorial ...
O. Hernandez-Mendo, J.D. Leaver
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Estrutura da pastagem e padrões de desfolhação em capim-mombaça em diferentes alturas do dossel forrageiro Sward structure and defoliation patterns in mombaçagrass according to different canopy heights

Revista Brasileira de Zootecnia, 2005
Com o objetivo de avaliar o padrão de desfolhação em pastagens de capim-mombaça (Panicum maximum, Jacq.), novilhas leiteiras da raça HPB foram submetidas, em testes de pastejo, a cinco alturas de dossel (60, 80, 100, 120 e 140 cm), em um delineamento ...
Ana Luisa Palhano, Paulo César de Faccio Carvalho, João Ricardo Dittrich, Aníbal de Moraes, Marsânia Zap Barreto, Melony Caroline Ferreira dos Santos   +5 more
doaj   +1 more source

Foraging ecology of fall-migrating shorebirds in the Illinois River valley. [PDF]

PLoS ONE, 2012
Populations of many shorebird species appear to be declining in North America, and food resources at stopover habitats may limit migratory bird populations.
Randolph V Smith, Joshua D Stafford, Aaron P Yetter, Michelle M Horath, Christopher S Hine, Jeffery P Hoover   +5 more
doaj   +1 more source

The diet and habitat utilisation of the badger (Meles meles) in an area to the South of Durham city [PDF]

, 1992
The study investigates the diet and habitat utilisation of five badger clans in an area of mixed woodland, pasture and arable land between mid May and mid July 1992.
Fletcher, J.G.
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source