Results 61 to 70 of about 757,698 (311)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Weight management interventions in adults with intellectual disabilities and obesity: a systematic review of the evidence [PDF]

, 2013
o evaluate the clinical effectiveness of weight management interventions in adults with intellectual disabilities (ID) and obesity using recommendations from current clinical guidelines for the first line management of obesity in adults.
A Avenell, A Bowling, A Jinks, AB Biswas, AB Sailer, AF Rotatori, AT Bazzano, CA Melville, Catherine Ruth Hankey, CJ Greaves, CL Wu, Craig Andrew Melville, D Marshall, D Moher, D Spanos, DA Renjilian, Dimitrios Spanos, E Fisher, E Loveman, G Ewing, G Frost, GV Mendonca, HJ Jackson, I Moroshko, J Douketis, J Geller, J Grimshaw, J Mahy, J Mann, J Stevens, J Ziviani, JH Rimmer, JJ Jacob, JM Jakicic, K McDonald, K Shaw, K Wynne, KM McTigue, L Matthews, M Antal, M Campbell, M Ham, M Harris, MJ Chapman, MJ Chapman, MS McCarran, National Institute for Health and Clinical Excellence (NICE), National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) North American Association for the Study of Obesity (NAASO), P Willner, RA Fox, RA Fox, RJ Stancliffe, RR Saunders, S Bertoli, S Bradley, S Cleaver, S Hamilton, Scottish Intercollegiate Guideline Network (SIGN), SJ Moss, T Heller, T Iacono, VA Catenacci   +61 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Prospective evaluation of a protocol for transitioning porcine lente insulintreated diabetic cats to human recombinant protamine zinc insulin [PDF]

, 2018
Objectives The objective was to evaluate a nadir-led protocol for transitioning porcine lente insulin suspension (PLIS)-treated diabetic cats onto human recombinant protamine zinc insulin (PZIR). Methods Recently diagnosed (
Church, D B, Forcada, Y, Gostelow, R, Hazuchova, K, Niessen, S J M, Scudder, C   +5 more
core   +2 more sources

Diet therapy for rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1983
AbstractAlthough diet therapy for arthritis has received considerable publicity, there is little objective information about its efficacy. We undertook a 10‐week, controlled, double‐blind, randomized trial of patients with active rheumatoid arthritis (RA). Twenty‐six patients completed the study; 11 were on an experimental diet (a specific popular diet
R S, Panush, R L, Carter, P, Katz, B, Kowsari, S, Longley, S, Finnie   +5 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The association between dietary inflammatory index and dietary total antioxidant capacity and Hashimoto’s thyroiditis: a case-control study

BMC Endocrine Disorders
Background Hashimoto’s thyroiditis (HT) is an inflammatory disease characterized by increased reactive oxygen species. Diets rich in anti-inflammatory and antioxidant properties may be linked to a reduced risk of developing HT.
Sepideh Alijani, Maliheh Ghadir, Bahram Pourghassem Gargari   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effect of Probiotic Fermented Milk (Kefir) on Glycemic Control and Lipid Profile In Type 2 Diabetic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Iranian Journal of Public Health, 2015
Background: Diabetes is a global health problem in the world. Probiotic food has anti-diabetic property. The aim of this trial was to determine the effect of probiotic fermented milk (kefir) on glucose and lipid profile control in patients with type 2 ...
Alireza Ostadrahimi, Akbar Taghizadeh, Majid Mobasseri, Nazila Farrin, Laleh Payahoo, Zahra Beyramalipoor Gheshlaghi, Morteza Vahedjabbari   +6 more
doaj