Results 241 to 250 of about 2,474,608 (304)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Comparison of Aflatoxin Contamination and Dietary Exposure From Complementary Foods Among Rural Tanzanian Infants Enrolled in the Mycotoxin Mitigation Trial. [PDF]

Food Sci Nutr
Kayanda RA, Kassim N, Phillips E, Turner PC, Stoltzfus R, Ngure FM.   +5 more
europepmc   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Trends in diet and exposure to chemicals in Dutch children [PDF]

, 2009
Jansen, M.C.J.F., Asselt, E.D., van, Bakker, M.I., Kruizinga, A.G., Boon, P.E.   +4 more
core  

Dietary exposure to creatine-precursor amino acids in the general population. [PDF]

Amino Acids
Nedeljkovic D, Ostojic SM.
europepmc   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Occurrence and Dietary Exposure Assessment of Quinolone Antibiotics in Animal-Derived Foods and Associated Health Risks Among Different Population Groups in Guangzhou, China. [PDF]

Foods
Xie Z, Wang Y, Chen Y, Li Y, Zhang Y, Liu L, Peng R, Zhang W, Mao YH.   +8 more
europepmc   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Polystyrene microplastics reduce the food chain transfer and toxicity of TiO₂ nanoparticles in crustacean <i>Artemia salina</i> through dietary exposure of microalga <i>Chlorella</i> sp.: impact of visible light and ultraviolet-A radiation. [PDF]

RSC Adv
Rex M C, Gupta MK, Sudandiradoss C, Mukherjee A.   +3 more
europepmc   +1 more source

Dietary exposure and health risk assessment of fumonisins through the consumption of maize and maize-based gluten-free products in individuals with celiac disease. [PDF]

Front Nutr
Tuyben EE, Sevim S, Macit A, Kizil M.
europepmc   +1 more source