Results 81 to 90 of about 2,469,952 (262)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

The association between dietary insulin index and load with depression, anxiety and stress in university students: a cross-sectional study

Scientific Reports
Mental disorders are considered as one of the most important concerns among university students, potentially impacting their quality of life and academic performance.
Hossein Nassaji-Jahromi, Sanaz Joekar, Akram Yazdani, Azadeh Aminianfar   +3 more
doaj   +1 more source

Dietary food patterns and glucose/insulin homeostasis: a cross-sectional study involving 24,182 adult Americans

Lipids in Health and Disease, 2017
Aim To investigate the association of major dietary patterns with glucose and insulin homeostasis parameters in a large American sample. The association between dietary patterns (DP) derived via principal components analysis (PCA), with glucose/insulin ...
Mohsen Mazidi, Andre Pascal Kengne, Dimitri P. Mikhailidis, Peter P. Toth, Kausik K. Ray, Maciej Banach   +5 more
doaj   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris

, 2016
Background. There is increasing evidence to support the relationship between acne vulgaris and diet. Objective. The aim of this study was to investigate possible associations among dietary glycemic index, glycemic load, milk consumption, insulin ...
Ozturk, Feyza Yener, Altunay, Ilknur Kivanc, Arici, Janset Erkul, Tulunay, Aysin, Aktas, Ezgi, Cerman, Asli Aksu   +5 more
core   +2 more sources

Association between dietary insulin index and postmenopausal osteoporosis in Iranian women: a case-control study

BMC Women's Health
Background The relationship between the dietary insulin index (DII) and the disease’s risk is unknown, despite the fact that hyperinsulinemia is presumed to contribute to osteoporosis. The insulin response of various diets determines the DII.
Shakiba Solgi, Farid Zayeri, Behnood Abbasi   +2 more
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Concurrent Beet Juice and Carbohydrate Ingestion: Influence on Glucose Tolerance in Obese and Nonobese Adults

Journal of Nutrition and Metabolism, 2017
Insulin resistance and obesity are characterized by low nitric oxide (NO) bioavailability. Insulin sensitivity is improved with stimulation of NO generating pathways.
Joseph W. Beals, Scott E. Binns, Janelle L. Davis, Gregory R. Giordano, Anna L. Klochak, Hunter L. Paris, Melani M. Schweder, Garrett L. Peltonen, Rebecca L. Scalzo, Christopher Bell   +9 more
doaj   +1 more source

Positive association between dietary acid load and future insulin resistance risk: findings from the Korean Genome and Epidemiology Study

Nutrition Journal, 2020
Background Acid-base homeostasis is increasingly being recognized to play an important role in normal metabolic function. However, prospective studies on the relationship between diet-induced acid-base imbalance and insulin resistance among Asian ...
Kyung Won Lee, Dayeon Shin
doaj   +1 more source