Results 41 to 50 of about 284,825 (259)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

The nature of the dietary protein impacts the tissue-to-diet 15N discrimination factors in laboratory rats. [PDF]

open access: yesPLoS ONE, 2011
Due to the existence of isotope effects on some metabolic pathways of amino acid and protein metabolism, animal tissues are (15)N-enriched relative to their dietary nitrogen sources and this (15)N enrichment varies among different tissues and metabolic ...
Nathalie Poupin   +5 more
doaj   +1 more source

The effect of the addition of soluble fibers (polydextrose, corn, pea) on the color, texture, structural features and protein digestibility of semolina pasta

open access: yesApplied Food Research, 2022
Wheat durum pasta was added with dietary fiber from green pea, corn or polydextrose at levels of 6, 12 and 18 g/100 g. Texture analysis showed that the dietary fiber produced cooked pasta with increased hardness, reduced elasticity and cohesiveness, the ...
M.E. Rodriguez-Huezo   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dietary Protein and Physical Exercise for the Treatment of Sarcopenia

open access: yesClinics and Practice
Sarcopenia is a multifactorial age-related disorder that causes a decrease in muscle mass, strength, and function, leading to alteration of movement, risk of falls, and hospitalization.
Rosarita Nasso   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Color‐Coding Dietary Proteins by Source Based on Impacts of Their Production and Consumption on the Planet and the People—Redefining Proteins in the Future Food Systems

open access: yesFood Frontiers
Protein is a versatile polymer with diverse nutritional and technological functionalities that are important for human health. Traditional protein sources are being evaluated for the sustainability of their production and the health consequences ...
Tadesse Fikre Teferra
doaj   +1 more source

Food Neophobia and Animal Protein Intake in Children Aged 3-5 Years

open access: yesDiversity
Food neophobia, defined as the avoidance of unfamiliar or familiar foods due to fear and negative perceptions, can significantly influence children’s dietary variety and nutritional adequacy. Previous studies have highlighted inconsistent findings on its
Novia Tri Khoirunnisa   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Effect of dietary protein source on calcium phosphorus product in patients with chronic kidney disease

open access: yesGiornale di Clinica Nefrologia e Dialisi
Introduction: Cardiovascular disease is highly prevalent in chronic kidney disease (CKD) and progresses rapidly. The calcium–phosphorus product (Ca×P) is a clinically relevant mineral metabolism parameter linked to cardiovascular risk in CKD. This study
Sinem Bayram   +2 more
doaj   +1 more source

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