Results 41 to 50 of about 219,155 (259)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Policy Brief: Policy Options to Reduce Salt Consumption in Iran [PDF]
Taṣvīr-i salāmatBackground. Non-communicable diseases (NCDs), such as cardiovascular diseases and hypertension, are the leading causes of mortality in Iran. High salt intake is one of the major contributors to these diseases.
Mitra Sarmadikia +3 more
doaj +1 more source
Frontiers in Nutrition, 2022 BackgroundSalt reduction strategies help reduce the risk of cardiovascular diseases (CVDs) by reducing high blood pressure. This study aimed to assess salt related knowledge, attitude, and practices (KAP) before and after administering an evidence-based ...
Leila Cheikh Ismail +14 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Validation of an online tool to estimate sodium consumption in the Mexican population
Archivos Latinoamericanos de NutriciónIntroduction: A new online, self-administered questionnaire called the “Sodium Calculator” (SC) was developed in Mexico, designed to provide immediate feedback on their sodium intake. Objective: This study aimed to evaluate the reliability and concurrent
Patricio Benítez-Alday +6 more
doaj +1 more source
Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review
Antioxidants, 2023 (1) Introduction: Restriction in sodium intake is an important strategy for reducing cardiovascular morbidity and mortality, considering the direct influence of high-sodium diet consumption on the development of hypertension and cardiovascular diseases ...
Guilherme da Silva Ferreira +2 more
doaj +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Dietary Sodium for Laying Hens
Poultry Science, 1977 Dietary sodium requirements of laying hens in open type and evaporatively cooled housing were determined to be 0.126 and 0.145% of the diet, respectively. The lowest level of 0.04% sodium supported average rates of production of 49.1 and 60.3% in the two houses for the 28 weeks of the study.
openaire +2 more sources
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Clinical and Experimental Hypertension, 2018 Objective: There is an interaction between dietary sodium/potassium intake in the pathogenesis of hypertension (HTN) and cardiovascular disease (CVD). The aim of this study was to investigate the association of dietary sodium to potassium (Na/K) ratio ...
Parvin Mirmiran +3 more
doaj +1 more source