Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time. [PDF]
Environ Health PerspectBackground: Global and site-specific changes in DNA methylation and gene expression are associated with cardiovascular development, aging, and disease, but how the transcriptome and epigenome of the heart change across the life course in males vs ...
Wang K +5 more
europepmc +2 more sources
Association of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis. [PDF]
Am J Transl ResOBJECTIVE Evidence suggests that diethylhexyl phthalate (DEHP) may disrupt thyroid hormone homeostasis by targeting multiple components of the hypothalamic-pituitary-thyroid (HPT) axis, potentially harming human health.
Xu K +5 more
europepmc +2 more sources
A survey of phthalates in flavored olive oils from Turkey
Grasas y Aceites, 2023 Phthalates are organic contaminants that are used as plasticizers in many plastic food packaging materials. Because of their lipophilic character, oils are the primary source of human exposure to phthalates. In this study, the presence of five phthalate
İ. Toptancı +2 more
doaj +1 more source
Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans. [PDF]
PLoS Genet, 2020 Exposure to diethylhexyl phthalate (DEHP), the most abundant plasticizer used in the production of polyvinyl-containing plastics, has been associated to adverse reproductive health outcomes in both males and females.
Cuenca L +7 more
europepmc +2 more sources
Diethylhexyl phthalate induces teratogenic effects through oxidative stress response in a chick embryo model. [PDF]
Toxicol Res (Camb), 2020 Diethylhexyl phthalate (DEHP) is known as a persistent environmental pollutant. However, the possible effects of DEHP on human neural tube defects (NTDs) remain elusive.
Song G +5 more
europepmc +2 more sources
Association Between Di-(2-Ethylhexyl) Phthalate and Childhood Asthma Through Plasma Metabolome Alterations. [PDF]
AllergyAllergy, Volume 81, Issue 1, Page 304-306, January 2026.
Kim MJ +21 more
europepmc +2 more sources
DEHP Down-Regulates Tshr Gene Expression in Rat Thyroid Tissues and FRTL-5 Rat Thyrocytes: A Potential Mechanism of Thyroid Disruption [PDF]
Endocrinology and Metabolism, 2021 Background Di-2-ethylhexyl phthalate (DEHP) is known to disrupt thyroid hormonal status. However, the underlying molecular mechanism of this disruption is unclear. Therefore, we investigated the direct effects of DEHP on the thyroid gland.
Min Joo Kim +7 more
doaj +1 more source
Independent and combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm quality in the human and dog. [PDF]
Sci Rep, 2019 A temporal decline in human and dog sperm quality is thought to reflect a common environmental aetiology. This may reflect direct effects of seminal chemicals on sperm function and quality.
Sumner RN +4 more
europepmc +2 more sources
Phthalate exposure and childhood obesity [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Phthalates are commonly used as plasticizers and vehicles for cosmetic ingredients. Phthalate metabolites have documented biochemical activity including activating peroxisome proliferator-activated receptor and antiandrogenic effects, which may ...
Shin Hye Kim, Mi Jung Park
doaj +1 more source
Release of phthalate esters in pasteurized milk samples with plastic packaging
International Journal of Environmental Health Engineering, 2020 Aim: In this study, the presence of four phthalate esters, including diethyl phthalate (DEP), Dibutyl phthalate, benzyl butyl phthalate (BBP), and diethylhexyl phthalate (DEHP) in pasteurized milk with plastic packages was investigated during the time ...
Fatemeh Moradian +3 more
doaj +1 more source