Results 161 to 170 of about 12,555 (220)

Effect of diazepam on microsomal diethylnitrosamine metabolism in gerbils

Journal of Cancer Research and Clinical Oncology, 1982
Dealkylation of diethylnitrosamine (DEN) by a liver microsomal fraction was measured after treatment of the Mongolian gerbil with DEN, Valium, or DEN plus Valium. Valium-dosed male and female animals showed strongly stimulated deethylase levels compared with the controls. This was also true of the DEN-treated females.
P, Conradt, U, Green
openaire   +2 more sources

Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats.

Food and Chemical Toxicology, 2019
Neferine is a bisbenzylisoquinoline alkaloid isolated from the embryos of lotus which has attracted attention for its anti-inflammatory and anti-cancer activities.
Kalaiselvi Sivalingam, V. Amirthalingam, K. Ganasan, Chih-Yang Huang, V. Viswanadha   +4 more
semanticscholar   +1 more source

Fluoride and diethylnitrosamine coexposure enhances oxido‐inflammatory responses and caspase‐3 activation in liver and kidney of adult rats

Journal of biochemical and molecular toxicology, 2019
The present study investigated the impact of coexposure to fluoride and diethylnitrosamine (DEN) on hepatorenal function in adult rats. The animals were exposed to fluoride (15 mg/L in drinking water) and DEN (10 mg/kg) singly or coexposed to both ...
S. Owumi, N. O. Aliyu-Banjo, Olabisi F Danso   +2 more
semanticscholar   +1 more source

Carcinomas of the esophagus in rats ingesting diethylnitrosamine

European Journal of Cancer (1965), 1975
Abstract Buffalo strain male and female rats 12 weeks of age ingested 0·0114% diethylnitrosamine (DEN) in the diet for 26 weeks and were returned to the basal diet without DEN for the remainder of the experiment. Rats survived an average of 28 weeks.
openaire   +2 more sources

Effects of butylated hydroxytoluene alone or with diethylnitrosamine in mice

Food and Cosmetics Toxicology, 1974
Abstract Mice (18 months old) given butylated hydroxytoluene (BHT) at a dietary level of 0·75% for 16 months had 63·6% of lung tumours compared with 24·0% in controls. Mice given dietary BHT as well as diethylnitrosamine (DENA) in the drinking-water (average total intake 330 mg DENA/kg) had more lung tumours per mouse (4·0) than did the controls or ...
N K, Clapp, R L, Tyndall, R B, Cumming, J A, Otten   +3 more
openaire   +2 more sources

Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine‐induced hepatocellular carcinoma

Journal of Pineal Research, 2018
Disruption of circadian rhythms, which are regulated by the circadian clock machinery, plays an important role in different long‐term diseases including hepatocellular carcinoma (HCC). Melatonin has been reported to alleviate promotion and progression of
D. I. Sánchez, Bárbara González-Fernández, Irene Crespo, B. San-Miguel, M. Álvarez, J. González‐Gallego, M. Tuñón   +6 more
semanticscholar   +1 more source

Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats.

Journal of Environmental Pathology And Toxicology, 2020
Liver cancer or hepatocellular carcinoma is considered to be the third leading cause of death among all other cancers. The rate of liver cancer occurrence is high, and the rate of recovery is low.
Chunyang Zhang, Yuhui Chen, Ming Zhang, Chun-mei Xu, G. Gong, V. Veeraraghavan, S. Bolla, Yandong Li   +7 more
semanticscholar   +1 more source

Temporal Advancement of Diethylnitrosamine Carcinogenesis in Aging Mice

Journal of Gerontology, 1981
Female BALB/c mice were given diethylnitrosamine (DEN) in their drinking water beginning at 2.5, 9.5, and 17 months of age (cumulative dose approximately 300 to 400 mg/kg body weight) or were untreated. Median times of death for the treatment groups were 193, 168, and 125 days, respectively, after cessation of DEN treatment and were significantly ...
Clapp, N K, Perkins, E H, Klima, W C, Cacheiro, L H   +3 more
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Ferritin is increased in diethylnitrosamine - altered rat hepatocytes

Biochemical and Biophysical Research Communications, 1981
Abstract Ferritin was localized by immunoperoxidase in rat liver during the early stages of experimental carcinogenesis induced by diethylnitrosamine. Carcinogen - altered hepatocytes, indentified by their reduction in membrane-bound ATPase activity, showed a highly elevated content in ferritin (or ferritin subunits), compared to normal hepatocytes ...
C, Beaumont, E, Le Rumeur, C, Guillouzo, M F, Latinier, M, Bourel, A, Guillouzo   +5 more
openaire   +2 more sources

Hepatoprotective effect of boldine against diethylnitrosamine‐induced hepatocarcinogenesis in wistar rats

Journal of biochemical and molecular toxicology, 2019
Discovering the utmost effective and targeted chemotherapy for hepatocellular carcinoma is still a significant challenge. In the present study, diethylnitrosamine was used as a liver carcinogen and boldine a compound of boldo.
N. Subramaniam, P. Kannan, A. K, Devaki Thiruvengadam   +3 more
semanticscholar   +1 more source