Results 121 to 130 of about 8,209,000 (311)

On a New Class of Fractional Difference-Sum Operators with Discrete Mittag-Leffler Kernels

open access: yes, 2019
We formulate a new class of fractional difference and sum operators, study their fundamental properties, and find their discrete Laplace transforms. The method depends on iterating the fractional sum operators corresponding to fractional differences with
Thabet Abdeljawad, Arran Fernandez
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Caution Regarding the Difference Between Flower-Like Lymphocytes and Flower-Like Plasma Cells

open access: yesTurkish Journal of Hematology, 2022
Jingnan Zhu   +3 more
doaj   +1 more source

In Search for Forgiveness [PDF]

open access: yesMeta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2011
Review of: Simon D. Podmore, Kierkegaard and the Self Before God Anatomy of the Abyss, Indiana Series in the Philosophy of Religion, Bloomington, 2011, 280p.
Ionut Barliba
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity, difference and belonging in childhood: Issues for foster care and identities

open access: yesSocial Work and Society, 2017
Since the 1970s, those who support and those who oppose ‘transracial’ fostering and adoption have often been deeply divided. In transracial placements, diversity, difference and belonging are at the heart of developments in foster care and adoption. Yet,
Ann Phoenix
doaj  

Becoming known: Disclosure and exposure of (in)visible difference.

open access: yes, 2020
Bodily or physical differences constitute a class of potentially stigmatized characteristics. The existing literature confirms that those with appearance altering or disfiguring conditions (“visible differences”) may experience both felt and enacted ...
Williamson, Heidi   +3 more
core   +1 more source

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