Results 101 to 110 of about 12,319,152 (351)

Some Newton’s inequalities on co-ordinates for Riemann–Liouville fractional integrals

Miskolc Mathematical Notes
In this paper, we give an identity involving Riemann–Liouville fractional integrals and partially differentiable function of two variables. Then, we use the newly established identity and prove some new Newton’s type inequalities for differentiable co ...
Fatih Hezenci, Tuba Tunç, Hüseyin Budak, Muhammad Aamir Ali   +3 more
doaj   +1 more source

Weakened subdifferentials and Frechet differentiability of real functions [PDF]

Let X be a real Banach space and f : X ! R [ {+1}. It is well known that the Clarke subdifferential @ f(x) of the function f at x 2 int dom f is a singleton if and only if f is strongly differentiable (then @ f(x) = {Dsf(x)}, where Dsf(x) is the strong ...
Ginchev Ivan
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Hermite–Hadamard–Mercer Inequalities Associated with Twice-Differentiable Functions with Applications

Axioms
In this work, we initially derive an integral identity that incorporates a twice-differentiable function. After establishing the recently created identity, we proceed to demonstrate some new Hermite–Hadamard–Mercer-type inequalities for twice ...
Muhammad Aamir Ali, Thanin Sitthiwirattham, Elisabeth Köbis, Asma Hanif   +3 more
doaj   +1 more source

Extending the Applicability of a Two-Step Chord-Type Method for Non-Differentiable Operators

Mathematics, 2019
The semi-local convergence analysis of a well defined and efficient two-step Chord-type method in Banach spaces is presented in this study. The recurrence relation technique is used under some weak assumptions.
Ioannis K. Argyros, Neha Gupta, J. P. Jaiswal   +2 more
doaj   +1 more source

Differentiable even functions

Duke Mathematical Journal, 1943
Not ...
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Opial inequalities for a conformable ∆-fractional calculus on time scales [PDF]

Mathematica Moravica
In this paper, an Opial-type inequality is introduced on time scale for a conformal ∆-fractional differentiable function of order a, a ∈ (0, 1]. In the case where the certain weight functions are included, one generalization of the Opial inequality is ...
Mirković Tatjana, Bajić Tatjana
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

On some inequalities related to open Newton-Cotes formulas for differentiable convex functions with applications

Miskolc Mathematical Notes
In this paper, first, we prove a novel integral identity involving a single time-differentiable function. Then, we prove some new inequalities associated with one of the open Newton-Cotes formulas for differentiable convex functions.
Ifra Bashir Sial, Sun Mei, Muhammad Aamir Ali, Hüseyin Budak   +3 more
doaj   +1 more source