Results 81 to 90 of about 213,817 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Data mining methods for the prediction of intestinal absorption using QSAR [PDF]

, 2014
Oral administration is the most common route for administration of drugs. With the growing cost of drug discovery, the development of Quantitative Structure-Activity Relationships (QSAR) as computational methods to predict oral absorption is highly ...
Newby, Danielle Anne
core  

Time-resolved diffuse optical spectroscopy: a differential absorption approach

, 2009
Time-resolved diffuse optical spectroscopy: a differential absorption ...
CUBEDDU, RINALDO, SPINELLI, LORENZO, Antonio Pifferi, Andrea Bassi, PIFFERI, ANTONIO GIOVANNI, BASSI, ANDREA, Rinaldo Cubeddu, TARONI, PAOLA, Paola Taroni, Lorenzo Spinelli   +9 more
core   +1 more source

Alternative method for concentration retrieval in differential optical absorption spectroscopy atmospheric gas pollutant measurements [PDF]

, 2003
Differential optical absorption spectroscopy is a widely used technique for open-column atmospheric-gas pollution monitoring. The concentration retrieval is based on the fitting of the measured differential absorbance through the Lambert-Beer law.
Videla, Fabián Alfredo, Tocho, Jorge Omar, Schinca, Daniel Carlos   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Time-Resolved Broadband Diffuse Spectroscopy Using a Differential Absorption Approach

, 2010
Time-Resolved Broadband Diffuse Spectroscopy Using a Differential Absorption ...
CUBEDDU, RINALDO, SPINELLI, LORENZO, Antonio Pifferi, Andrea Bassi, PIFFERI, ANTONIO GIOVANNI, BASSI, ANDREA, Rinaldo Cubeddu, TARONI, PAOLA, Lorenzo Spinelli, Paola Taroni   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

High-Resolution Nitrogen Dioxide Measurements from an Airborne Fiber Imaging Spectrometer over Tangshan, China

Remote Sensing
The pollution caused by nitrogen dioxide is a major environmental problem in China. This study introduces a new type of atmospheric trace gas remote-sensing instrument, an airborne fiber imaging spectrometer. This spectrometer has a spectral range of 300–
Xiaoli Zhang, Liang Xi, Haijin Zhou, Wei Wang, Zhen Chang, Fuqi Si, Yu Wang   +6 more
doaj   +1 more source

On the performance of heat absorption/generation and thermal stratification in mixed convective flow of an Oldroyd-B fluid

Nuclear Engineering and Technology, 2017
This investigation explores the thermally stratified stretchable flow of an Oldroyd-B material bounded by a linear stretched surface. Heat transfer characteristics are addressed through thermal stratification and heat generation/absorption.
Tasawar Hayat, Muhammad Ijaz Khan, Muhammad Waqas, Ahmed Alsaedi   +3 more
doaj   +1 more source