Results 61 to 70 of about 45,034 (273)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Neural Network Trajectory Tracking Control on Electromagnetic Suspension Systems
Mathematics, 2023 A new adaptive-like neural control strategy for motion reference trajectory tracking for a nonlinear electromagnetic suspension dynamic system is introduced. Artificial neural networks, differential flatness and sliding modes are strategically integrated
Francisco Beltran-Carbajal +5 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
International Journal of Advanced Robotic Systems, 2011 The paper proposes derivative-free nonlinear Kalman Filtering for MIMO nonlinear dynamical systems. The considered nonlinear filtering scheme which is based on differential flatness theory extends the class of systems to which Kalman Filtering can be ...
Gerasimos G. Rigatos
doaj +1 more source
Geometry and flatness of m-crane systems [PDF]
Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019 We propose a class of m-crane control systems, that generalizes two- and three-dimensional crane systems. We prove that each representant of the described class is feedback equivalent to the second order chained form with drift.
M. Nowicki +3 more
doaj +1 more source
Modeling of Cerebral Blood Flow Autoregulation Using Mathematical Control Theory
Mathematics, 2022 A mathematical model of cerebral blood flow in the form of a dynamical system is studied. The cerebral blood flow autoregulation modeling problem is treated as a nonlinear control problem and the potential and applicability of the nonlinear control ...
Alexey Golubev +2 more
doaj +1 more source
The nonholonomic Riemann and Weyl tensors for flag manifolds [PDF]
, 2005 On any manifold, any non-degenerate symmetric 2-form (metric) and any skew-symmetric (differential) form W can be reduced to a canonical form at any point, but not in any neighborhood: the respective obstructions being the Riemannian tensor and dW.
Dimitry A. Leites +5 more
core +1 more source
Some Counterexamples Concerning a Differential Criterion for Flatness [PDF]
Proceedings of the American Mathematical Society, 1981 Let A denote a commutative ring with identity. We suppose A contains a field k of characteristic zero. Let Ql(A) and d: A -gl(A) denote the A-module of first-order k-differentials on A and the canonical derivation of A into 0'(A) respectively. If % is an ideal of A which is flat as an A-module, then xdy ydx E %2Qk(A) for all xy in W.
Brown, William C., Glaz, Sarah
openaire +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source