Results 61 to 70 of about 45,098 (292)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Geometry and flatness of m-crane systems [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019
We propose a class of m-crane control systems, that generalizes two- and three-dimensional crane systems. We prove that each representant of the described class is feedback equivalent to the second order chained form with drift.
M. Nowicki, W. Respondek, J. Piasek, K. Kozłowski   +3 more
doaj   +1 more source

Neural Network Trajectory Tracking Control on Electromagnetic Suspension Systems

Mathematics, 2023
A new adaptive-like neural control strategy for motion reference trajectory tracking for a nonlinear electromagnetic suspension dynamic system is introduced. Artificial neural networks, differential flatness and sliding modes are strategically integrated
Francisco Beltran-Carbajal, Hugo Yañez-Badillo, Ruben Tapia-Olvera, Julio C. Rosas-Caro, Carlos Sotelo, David Sotelo   +5 more
doaj   +1 more source

The nonholonomic Riemann and Weyl tensors for flag manifolds [PDF]

, 2005
On any manifold, any non-degenerate symmetric 2-form (metric) and any skew-symmetric (differential) form W can be reduced to a canonical form at any point, but not in any neighborhood: the respective obstructions being the Riemannian tensor and dW.
Dimitry A. Leites, Dimitry Leites, Pavel Grozman, Pavel Grozman, The Nonholonomic Riemann, Weyl Tensors   +5 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Derivative-Free Nonlinear Kalman Filtering for MIMO Dynamical Systems: Application to Multi-DOF Robotic Manipulators

International Journal of Advanced Robotic Systems, 2011
The paper proposes derivative-free nonlinear Kalman Filtering for MIMO nonlinear dynamical systems. The considered nonlinear filtering scheme which is based on differential flatness theory extends the class of systems to which Kalman Filtering can be ...
Gerasimos G. Rigatos
doaj   +1 more source

Modeling of Cerebral Blood Flow Autoregulation Using Mathematical Control Theory

Mathematics, 2022
A mathematical model of cerebral blood flow in the form of a dynamical system is studied. The cerebral blood flow autoregulation modeling problem is treated as a nonlinear control problem and the potential and applicability of the nonlinear control ...
Alexey Golubev, Andrey Kovtanyuk, Renée Lampe   +2 more
doaj   +1 more source

Some Counterexamples Concerning a Differential Criterion for Flatness [PDF]

Proceedings of the American Mathematical Society, 1981
Let A denote a commutative ring with identity. We suppose A contains a field k of characteristic zero. Let Ql(A) and d: A -gl(A) denote the A-module of first-order k-differentials on A and the canonical derivation of A into 0'(A) respectively. If % is an ideal of A which is flat as an A-module, then xdy ydx E %2Qk(A) for all xy in W.
Brown, William C., Glaz, Sarah
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Analysis of fluid-structure interaction vibration based on the detection principle of SI-FLAT flatness measurement systems

工程科学学报, 2017
In order to reveal the mechanical essence of the detecting principle of SI-FLAT flatness measurement systems, the mathematical model of the relationship between amplitude and residual stress was established, based on the theory of fluid-structure ...
LI Nong, KONG Ning, LI Hong-bo, ZHANG Jie, JIA Sheng-hui, CHU Yu-gang, LIU Hai-jun   +6 more
doaj   +1 more source