Results 81 to 90 of about 46,345 (342)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Spherically Symmetric Solutions in Higher-Derivative Gravity [PDF]

, 2015
Extensions of Einstein gravity with quadratic curvature terms in the action arise in most effective theories of quantised gravity, including string theory.
Lü, H., Perkins, A., Pope, C. N., Stelle, K. S.   +3 more
core   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Quadcopter Trajectory Tracking Control Based on Flatness Model Predictive Control and Neural Network

Actuators
In this paper, a novel control architecture is proposed in which FMPC couples feedback from model predictive control with feedforward linearization. The proposed approach has the computational advantage of only requiring a convex quadratic program to be ...
Yong Li, Qidan Zhu, Ahsan Elahi
doaj   +1 more source

Feedback control for steering support system based on flatness and particle swarm optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
In this study we give a feedback control method for steering support system. In this method we consider the stability of the path tracking control system under the limitation of steering angle, so that drivers can drive safer and more comfortable.
Michihiro KAWANISHI, Yuta TSUGE, Shi-Jia PEI, Tatsuo NARIKIYO   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Supersymmetric D-branes on flux backgrounds

, 2007
Several aspects concerning the physics of D-branes in Type II flux compactifications preserving minimal N=1 supersymmetry in four dimensions are considered. It is shown how these vacua are completely characterized in terms of properly defined generalized
Aspinwall, Becker, Benmachiche, Gmeiner, Graña, Graña, Graña, Gualtieri, Gutowski, Gutowski, Harvey, Hitchin, Kapustin, Kapustin, Koerber, Koerber, Martucci, Martucci, Minasian   +18 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Seguimiento de trayectorias en manipuladores robóticos usando Differential Flatness

Ingeniería e Investigación, 2011
Este documento propone una aplicación con Differential Flatness para el problema de seguimiento de trayectorias en manipuladores robóticos. Para cada coordenada generalizada, se proponen sus trayectorias como una función en el tiempo donde deben ...
Elkin Veslin Diaz, Jules Slama, Max Dutra, Omar Lengerke, Magda Morales Tavera   +4 more
doaj