Results 61 to 70 of about 18,040 (268)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

On a class of linear-state differential games with subgame individually rational and time consistent bargaining solutions

Journal of Mechanism and Institution Design, 2020
We consider n-person pure bargaining games in which the space of feasible payoffs is constructed via a normal form differential game. At the beginning of the game the agents bargain over strategies to be played over an infinite time horizon. An initial
Simon Hoof
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

IDP-Core: Novel Cooperative Solution for Differential Games

Mathematics, 2020
IDP-core is a new cooperative solution for dynamic and differential games. A novel approach of constructing solutions for dynamic and differential games was employed in which the time consistency property was used as the main axiom property for the ...
Ovanes Petrosian, Victor Zakharov
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

On the Effect of the Absorption Coefficient in a Differential Game of Pollution Control

Mathematics, 2020
We consider various approaches for a characteristic function construction on the example of an n players differential game of pollution control with a prescribed duration.
Ekaterina Marova, Ekaterina Gromova, Polina Barsuk, Anastasia Shagushina   +3 more
doaj   +1 more source

Empowering Adult Learning How AI Fuels Progress Across Disciplines and Professions

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of artificial intelligence (AI) as a transformative cognitive partner across educational and professional fields. It explores how AI shifts attention away from routine technical tasks and toward human‐centered skills such as critical thinking, ethical decision‐making, and professional judgment.
Rachel Wlodarsky
wiley   +1 more source

Differential Game-Based Cooperative Interception Guidance Law with Collision Avoidance

Aerospace
To deal with the offense-defense confrontation problem of multi-missile cooperative intercepting a high-speed and large-maneuvering target, a differential game-based cooperative interception guidance law with collision avoidance is proposed, in which the
Xueping Zhu, Xinxing Wang, Yue Li, Jun Yang   +3 more
doaj   +1 more source

Application of Difference Schemes to Decision the Pursuit Problem

Информатика и автоматизация, 2019
The problem of the pursuit curve construction in the case when the tangent to pursuer’s motion trajectory passes at any time through the point representing the pursued is considered. A new approach to construct the pursuit curves using difference schemes
Valery Fedorovich Ochkov, Inna Evgen'evna Vasileva   +1 more
doaj   +1 more source