Results 41 to 50 of about 18,040 (268)

Some Results on the Control of Polluting Firms According to Dynamic Nash and Stackelberg Patterns

Economies, 2021
In this paper we model the conflict between the group of polluting firms in a country and any social planner in the same country who attempts to control the volume of emissions generated during the production process.
George E. Halkos, George J. Papageorgiou
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dynamic Governance of Electric Vehicle Supply Chain Network Resilience Under Disruption Risks

Systems
In the context of multiple overlapping uncertainties, upstream disruptions in electric vehicle supply chain networks are becoming increasingly frequent. Given the dynamic and sudden nature of disruption risks, this paper introduces a stochastic stopping ...
Xuan Wang, Xiaoye Zhou, Meilin Zhu
doaj   +1 more source

A terrorism-based differential game: Nash differential game [PDF]

Advances in Difference Equations, 2021
AbstractIn this paper, we investigate the problem of combating terrorism by the government, which is one of the most serious problems that direct governments and countries. We formulate the problem and use the Nash approach of a differential game to obtain the optimal strategies for combating terrorism.
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Orbital Pursuit–Evasion–Defense Linear-Quadratic Differential Game

Aerospace
To find superior guidance strategies for preventing possible interception threats from space debris, out-of-control satellites, etc., this paper investigates an orbital pursuit–evasion–defense game problem with three players called the pursuer, the ...
Zhen-Yu Li
doaj   +1 more source

A Differential Game with Exit Costs [PDF]

Dynamic Games and Applications, 2019
We study a differential game where two players separately control their own dynamics, pay a running cost, and moreover pay an exit cost (quitting the game) when they leave a fixed domain. In particular, each player has its own domain and the exit cost consists of three different exit costs, depending whether either the first player only leaves its ...
Fabio Bagagiolo, Rosario Maggistro, Marta Zoppello   +2 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Differential game theory application in models of trade relations of Great Britain with Portugal and Russia with Belarus

Управление, 2018
The article includes the analysis of the current state of differential games theory based on the maximum principle of academician L. S. Pontryagin. The optimal solution of conflict, but not (strictly) analytical games and the question of the uniqueness ...
I. V. Korolyov
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source