Results 131 to 140 of about 2,296,453 (296)
Jixie chuandong, 2016 For the dual- cavity half toroidal continuously variable transmission mechanism composed of half toroidal continuously variable unit（ CVU）,the fixed- axis gear train and the double- row differential gear train,the condition of the transmission ratio of ...
Zhang Qinggong +3 more
doaj
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Differential Entropy-Based Fault-Detection Mechanism for Power-Constrained Networked Control Systems
EntropyIn this work, we consider the design of power-constrained networked control systems (NCSs) and a differential entropy-based fault-detection mechanism. For the NCS design of the control loop, we consider faults in the plant gain and unstable plant pole ...
Alejandro J. Rojas
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Universal Differential Mechanism
Biosciences Biotechnology Research Asia, 2014 Ildar Ilgizarovich Salakhov +3 more
openaire +1 more source
Differential allocation: tests, mechanisms and implications
Trends in Ecology & Evolution, 2000 Differential allocation occurs when reproductive investment is influenced by mate attractiveness. Recently, wide-ranging empirical support for differential allocation has been obtained. These data suggest that mates can affect the payoffs from reproduction, thus making sacrifices of reproductive value worthwhile when breeding with an attractive mate ...
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Differential Mechanism of ATP Production Occurs in Response to Succinylacetone in Colon Cancer Cells. [PDF]
Molecules, 2019 Lee PJ, Woo SJ, Yoo HM, Cho N, Kim HP.
europepmc +1 more source