Results 151 to 160 of about 3,536,382 (331)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Martingale interpretation of weakly cancelling differential operators [PDF]

open access: yesarXiv, 2019
We provide martingale analogs of weakly cancelling differential operators and prove a Sobolev-type embedding theorem for these operators in the martingale setting.
arxiv  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Univalent Functions Formulated by the Salagean-Difference Operator

open access: yesInternational Journal of Analysis and Applications, 2019
We present a class of univalent functions Tm(κ, α) formulated by a new differential-difference operator in the open unit disk. The operator is a generalization of the well known Salagean’s differential operator.
Rabha W. Ibrahim, Maslina Darus
doaj   +2 more sources

Differential evolution with biological-based mutation operator

open access: yesEngineering Science and Technology, an International Journal, 2020
Evolutionary algorithms are swiftly gaining recognition where the application of the same in solving complex real-world problems is beneficial. One of the best well known Evolutionary algorithms is Differential Evolution (DE).
Shashi Prabha, Raghav Yadav
doaj  

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri   +2 more
wiley   +1 more source

The Second Regularized Trace of Even Order Differential Operators with Operator Coefficient [PDF]

open access: yesarXiv, 2019
In this paper, we investigate the spectrum of the self adjoint differential operator with operator coefficitent in a separable Hilbert space. We also derive asymptotic formulas for the sum of eigenvalues of this operator.
arxiv  

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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