Results 91 to 100 of about 6,190 (152)

Electrochemical Detection of Heavy Metal (Pb Ions) and Pharmaceutical Waste (Ciprofloxacin) in Very Low Concentration Using β‐NaFeO2

Electrochemical Science Advances, Volume 6, Issue 4, August 2026.
Organic and inorganic pollutants detection in waste water using β‐NaFeO2 and inorganic pollutants detection in waste water using β‐NaFeO2. ABSTRACT Electrochemical techniques as a point of care analysis are drawing the researcher's attention, especially in the case of heavy metal ions (HMIs) detection. In this research, β‐NaFeO2 was synthesized using a
Md. Sahadat Hossain, Sumaya Tabassum, Israt Jahan Lithi, Priya Paul, Md. Kawsar, Md. Kawcher Alam, Md. Farid Ahmed, Samina Ahmed   +7 more
wiley   +1 more source

Radiobiology studies of gold nanoparticle‐enhanced radiosensitization in proton therapy

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Approximately 50%$\%$ of newly diagnosed cancer patients worldwide receive radiotherapy, most commonly with X‐rays. Proton therapy has emerged as a promising alternative, offering complementary advantages over conventional X‐rays due to its highly localized energy deposition at the Bragg peak, thereby reducing radiation exposure to ...
N. Fuster‐Martínez, D. H. Saucedo‐Cuberes, M. C. Jiménez‐Ramos, D. Esperante, J. M. Espino, J. Fuster, J. F. Belén‐Aguilar, L. González‐López, P. Huertas, S. Jimeno, I. Mingarro, D. Pascual, D. Suárez‐García, M. J. García‐Murria   +13 more
wiley   +1 more source

Deciphering the Function and Structure of PA1216 as an S‐Adenosyl‐l‐Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala, Jade X. Tiszler, Daniel Watson, Mansi Sinha, Tony D. Davis   +4 more
wiley   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, Volume 293, Issue 15, Page 4724-4743, August 2026.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Identification and development of oxoquinazoline derivatives as novel mycobacterial inhibitors targeting cell wall synthesis enzyme

Biomedical and Biotechnology Research Journal, 2018
Background: Tuberculosis (TB) still remains the leading cause of death worldwide and was unanswered till date. Available treatment strategies have many drawbacks such as longer treatment period, side effects, and drug interactions, which result in ...
Prasanthi Malapati, Krishna Siva Vagolu, Dhramarajan Sriram   +2 more
doaj   +1 more source

DNAJC12 Stabilizes Phenylalanine Hydroxylase and Facilitates Its Substrate‐Dependent Activation

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Substrate‐induced activation of PAH by L‐Phe involves dimerization of its regulatory domains (RD), with L‐Phe binding in the dimeric RD interface. The J‐domain protein DNAJC12 binds this activated conformation, stabilizing PAH and delaying aggregation, while reducing the substrate concentration required for activation.
Mary Dayne S. Tai, Trond‐André Kråkenes, Gloria Gamiz‐Arco, Christer F. Didriksen, Juha P. Kallio, Marte I. Flydal, Fernando Moro, Aurora Martinez   +7 more
wiley   +1 more source

Identification of relevant analytical methods for adeno-associated virus stability assessment during formulation development

Microbiology Spectrum
Formulation development for gene therapy viral vectors requires high-performance analytical methods that indicate or predict virus stability. Additionally, if testing involves multiple excipients, sample throughput must be sufficiently high, and the ...
Carina Rodenstein, Eva Schmid, Natalia Markova, Andreas Seidl   +3 more
doaj   +1 more source

Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors

mAbs
A critical attribute of therapeutic antibodies is their ability to engage with humoral or cellular effector mechanisms, and this depends on the ability of the Fc region to bind to complement (C1q) or Fc receptors.
Geoff Hale, Alastair Douglas Davy, Ian Wilkinson   +2 more
doaj   +1 more source

Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability

Computational and Structural Biotechnology Journal
Monoclonal antibodies with lambda (λ) light chains are less commonly used in therapeutics due to their lower biophysical stability compared to kappa (κ) variants.
Yead Jewel, Tynan Young, Miso Park, Kevin Ly, Asaul Gonzalez, T.Conn Mallett, John C. Williams   +6 more
doaj   +1 more source

Characterization of the pH-dependent protein stability of 3α-hydroxysteroid dehydrogenase/carbonyl reductase by differential scanning fluorimetry. [PDF]

Protein Sci, 2023
Chou YH, Hsieh CL, Chen YL, Wang TP, Wu WJ, Hwang CC.   +5 more
europepmc   +1 more source