Results 41 to 50 of about 176,220 (257)

ESTUDIO DEL INGRESO DE HIDRÓGENO EN ACERO ELECTROCINCADO MEDIANTE ANÁLISIS TÉRMICO

Avances en Ciencias e Ingeniería, 2020
The aim of this work is to study the hydrogen input in SAE 1005 steel wire samples during the successive stages of the electrolytic galvanizing process.
María N. Delpupo, Mariano N. Inés, Carolina A. Asmus, Graciela A. Mansilla   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Thermal Elastohydrodynamic Lubrication Analysis of Automotive Differential Bevel Gear Under Differential Condition

Jixie chuandong, 2019
In order to study the meshing thermal characteristics of the differential bevel gear under differential conditions， based on the thermal elastohydrodynamic lubrication theory， an unsteady thermal elastohydrodynamic lubrication model of straight bevel ...
Cong Wei, Youqiang Wang, Yabo Zhou, Shenwen Long   +3 more
doaj  

Impact of storage temperature and time on Moldavian dragonhead oil – spectroscopic and chemometric analysis

Open Chemistry, 2019
Moldavian dragonhead (Dracocephalum moldavica L.) is a plant endemic to Asia where it has been used for centuries for the production of essential oils. With the constantly growing demand for vegetable fats it is necessary to find new methods of ensuring ...
Oniszczuk Tomasz, Matwijczuk Arkadiusz, Matwijczuk Alicja, Kocira Sławomir, Niemczynowicz Agnieszka, Combrzyński Maciej, Wójtowicz Agnieszka, Kuboń Maciej, Kusz Andrzej, Oniszczuk Anna   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Nano-TiO₂ Dioxide on the Hydration Process of Tunnel Construction in Low-Temperature Environments

Nanomaterials
To address winter construction challenges such as slow early-stage strength development, inhibited hydration processes, and pore structure defects in concrete under low-temperature conditions, this study employs nano-TiO2 as a modifying agent.
Yongchun Jiao, Huijian Chen, Shengfu Xu, Fei Fu, Yipeng Tao, Sheng’ai Cui   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Thermal Analysis Investigation of Dapoxetine and Vardenafil Hydrochlorides using Molecular Orbital Calculations [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Thermal analysis techniques have been used to study the thermal behavior of dapoxetine and vardenafil hydrochlorides and confirmed using semi-empirical molecular orbital calculations.
Ali Kamal Attia, Eglal R. Souaya, Ethar A. Soliman   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source