Results 51 to 60 of about 24,508,395 (287)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Thermal, spectroscopic and DFT studies of solid benzamide
, 2014 Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and DFT theoretical calculations were used to study benzamide.
Chierice, Gilberto Orivaldo +5 more
core +3 more sources
A Heat Transfer Model Combining Differential and Integral Formulations for Thermal Analysis of Reciprocating Compressors [PDF]
, 2012 Heat transfer in hermetic compressors is a complex phenomenon strongly affected by fluid flow inside and outside the compression chamber and by the efficiency of both the electrical motor and the crankshaft mechanism.
Deschamps, Cesar J., Sanvezzo Jr, Joel
core +1 more source
The novel application of Fourier thermal analysis in foundry technologies
, 2014 The process of casting in sand moulds is used for a large volume of castings manufactured in the world. Internal channels and complex geometries of these products are formed by the placement of cores within the mould cavity. Resin-bound sand mixtures are
Svidró, József Tamás, +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Thermodynamic and Kinetic Study of Chromium Ore Reduction Using Complex Fe–Si–Cr and Al–Si–Cr Alloys
MetalsThis study investigates the thermodynamic and kinetic features of chromium reduction from chromium ore using complex Fe–Si–Cr and Al–Si–Cr alloys as reducing agents for the refined ferrochrome production.
Askhat Akuov +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source