Results 11 to 20 of about 1,609,951 (243)

Hunting for differentially expressed genes [PDF]

Brazilian Journal of Medical and Biological Research, 1999
Differentially expressed genes are usually identified by comparing steady-state mRNA concentrations. Several methods have been used for this purpose, including differential hybridization, cDNA subtraction, differential display and, more recently, DNA ...
C.G. Vedoy, M.H. Bengtson, M.C. Sogayar
doaj   +5 more sources

Detecting multivariate differentially expressed genes [PDF]

BMC Bioinformatics, 2007
Background Gene expression is governed by complex networks, and differences in expression patterns between distinct biological conditions may therefore be complex and multivariate in nature.
Tegnér Jesper, Björkegren Johan, Peña José M, Nilsson Roland   +3 more
doaj   +3 more sources

Differential gene expression in leiomyosarcoma [PDF]

Cancer, 2003
AbstractBACKGROUNDLeiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear.METHODSIn the current study, gene expression in LMS, leiomyomas, and normal myometrium was examined. RNA was prepared and gene expression was determined using microarray analysis arrays containing approximately 12,000 ...
Keith M, Skubitz, Amy P N, Skubitz
openaire   +2 more sources

Transcriptome analysis reveals differentially expressed genes associated with high rates of egg production in chicken hypothalamic-pituitary-ovarian axis

Scientific Reports, 2020
The hypothalamic-pituitary-ovarian (HPO) axis regulates the breeding process cycle of laying hens. However, the key regulatory genes of the HPO axis and pathways that drive chicken egg laying performance remain elusive.
S. Mishra, Binlong Chen, Qing Zhu, Zhongxian Xu, Chunyou Ning, H. Yin, Yan Wang, Xiaoling Zhao, Xiaolan Fan, Mingyao Yang, Deying Yang, Q. Ni, Yan Li, Mingwang Zhang, Diyan Li   +14 more
semanticscholar   +1 more source

Bioinformatics analysis of miRNA and mRNA expression profiles to reveal the key miRNAs and genes in osteoarthritis

Journal of Orthopaedic Surgery and Research, 2021
Background Osteoarthritis (OA) is a chronic degenerative joint disease and the most frequent type of arthritis. This study aimed to identify the key miRNAs and genes associated with OA progression.
Pei-yan Huang, Jun-guo Wu, Jun Gu, Tie-qi Zhang, Ling-feng Li, Si-qun Wang, Minghai Wang   +6 more
doaj   +1 more source

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Nature Communications, 2020
Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes, consequences or mere correlates of the disease under scrutiny.
E. Porcu, M. Sadler, Kaido Lepik, C. Auwerx, A. Wood, A. Weihs, Maroun Bou Sleiman, D. Ribeiro, S. Bandinelli, Toshiko Tanaka, M. Nauck, U. Völker, O. Delaneau, A. Metspalu, A. Teumer, T. Frayling, F. Santoni, A. Reymond, Z. Kutalik   +18 more
semanticscholar   +1 more source

Network analysis of potential risk genes for psoriasis

Hereditas, 2021
Background Psoriasis is a complex chronic inflammatory skin disease. The aim of this study was to analyze potential risk genes and molecular mechanisms associated with psoriasis.
Huilin Wang, Wenjun Chen, Jin He, Wenjuan Xu, Jiangwei Liu   +4 more
doaj   +1 more source

Reproducibility of Methods to Detect Differentially Expressed Genes from Single-Cell RNA Sequencing

Frontiers in Genetics, 2020
Detection of differentially expressed genes is a common task in single-cell RNA-seq (scRNA-seq) studies. Various methods based on both bulk-cell and single-cell approaches are in current use.
T. Mou, Wenjiang Deng, Fengyun Gu, Y. Pawitan, T. Vu   +4 more
semanticscholar   +1 more source

β-Glucosidase genes differentially expressed during composting

Biotechnology for Biofuels, 2020
Background Cellulose degradation by cellulase is brought about by complex communities of interacting microorganisms, which significantly contribute to the cycling of carbon on a global scale.
Xinyue Zhang, Bo Ma, Jiawen Liu, Xiehui Chen, Shanshan Li, Erlie Su, Liyuan Gao, Hongtao Li   +7 more
doaj   +1 more source

GENE EXPRESSION IN DIFFERENTIATED CELLS [PDF]

Proceedings of the National Academy of Sciences, 1963
This communication is concerned with the dynamics of gene control over specific biochemical functions in a differentiated cell. Direct experimental access to the intracellular link between gene action and the target cell characters has become feasible with the accumulation of evidence demonstrating that the synthesis of specific RNA's on the genomic ...
Davidson, E. H., Allfrey, V. G., Mirsky, A. E.   +2 more
openaire   +3 more sources