Results 51 to 60 of about 1,609,951 (243)

Differential gene expression during terminal erythroid differentiation

Genomics, 2007
Terminal erythroid differentiation in mammals is the process whereby nucleated precursor cells accumulate erythroid-specific proteins such as hemoglobin, undergo extensive cellular and nuclear remodeling, and ultimately shed their nuclei to form reticulocytes, which then become mature erythrocytes in the circulation.
Koury, S., Yarlagadda, S., Moskalik-Liermo, K., Popli, N., Kim, N., Apolito, C., Peterson, A., Zhang, X., Zu, P., Tamburlin, J., Bofinger, D.   +10 more
openaire   +2 more sources

Hybridization and gene expression: Beyond differentially expressed genes

Molecular Ecology
AbstractGene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Runemark, Anna, Moore, Emily C., Larson, Erica L.   +2 more
openaire   +3 more sources

Predictability of human differential gene expression [PDF]

Proceedings of the National Academy of Sciences, 2019
Differential expression (DE) is commonly used to explore molecular mechanisms of biological conditions. While many studies report significant results between their groups of interest, the degree to which results are specific to the question at hand is not generally assessed, potentially leading to inaccurate interpretation.
Crow, M, Lim, N, Ballouz, S, Pavlidis, P, Gillis, J   +4 more
openaire   +3 more sources

Omics Analysis Revealing Flavonoid Content During Maize Grain Germination

Metabolites
Background/Objectives: The germination process initiates an active process of secondary metabolism, which produces a series of secondary metabolites, including flavonoids. Methods: A metabolomics and transcriptomics analysis was conducted on maize grains
Xiaomin Tian, Lirong Chen, Linlin Sun, Kuijie Gong, Kaichang Liu, Yuqiu Guo   +5 more
doaj   +1 more source

Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer

Cancer Cell International, 2017
Methylation plays an important role in the etiology and pathogenesis of colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) and pathways in CRC by comprehensive bioinformatics analysis.
Jing-wei Liu, Hao Li, Liping Sun, Zhen-ning Wang, Chengzhong Xing, Yuan Yuan   +5 more
semanticscholar   +1 more source

Differential placental gene expression in preeclampsia [PDF]

The FASEB Journal, 2008
Objective: Candidate genes associated with preeclampsia have not been fully described. We conducted a microarray study to investigate global placental gene expression in preeclampsia. Study design: Cases (n=18) and controls (n=18) were selected among patients receiving care at Swedish Medical Center, Seattle, WA.
Daniel A, Enquobahrie, Margaret, Meller, Kenneth, Rice, Bruce M, Psaty, David S, Siscovick, Michelle A, Williams   +5 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Identification and role of differentially expressed genes/proteins between pulmonary tuberculosis patients and controls across lung tissues and blood samples

Immunity, Inflammation and Disease
Background Differentially expressed genes/proteins (DEGs/DEPs) play critical roles in pulmonary tuberculosis (PTB) diagnosis and treatment. However, there is a scarcity of reports on DEGs/DEPs in lung tissues and blood samples in PTB patients.
Qifeng Li, Kuerbanjiang Maierheba
doaj   +1 more source

Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma

BMC Cancer, 2019
Liver cancer is among top deadly cancers worldwide with a very poor prognosis, and the liver is a vulnerable site for metastases of other cancers. Early diagnosis is crucial for treatment of the predominant liver cancers, namely hepatocellular carcinoma (
A. Sarathi, Ashok Palaniappan
semanticscholar   +1 more source

Identification of Biomarkers Based on Differentially Expressed Genes in Papillary Thyroid Carcinoma

Scientific Reports, 2018
The incidence of papillary thyroid carcinoma (PTC) is increasing rapidly throughout the world. Hence, there is an urgent need for identifying more specific and sensitive biomarkers to explorate the pathogenesis of PTC. In this study, three pairs of stage
Jun Han, Meijun Chen, Yihan Wang, Boxuan Gong, T. Zhuang, Lingyu Liang, H. Qiao   +6 more
semanticscholar   +1 more source