Results 71 to 80 of about 3,651,834 (302)

In search of differentially expressed genes and proteins

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1997
A great challenge for modern cell biology is the successful examination of the co-expression of thousands of genes under physiological or pathological conditions and how the expression patterns define the different states of a single cell, tissue or a microorganism. Gene expression can be analyzed today on a large scale by advanced technical approaches
Vietor, Ilja, Huber, Lukas A
openaire   +2 more sources

Comprehensive transcriptome analysis based on RNA sequencing identifies critical genes for lipopolysaccharide-induced epididymitis in a rat model

Asian Journal of Andrology, 2019
Epididymitis is a commonly diagnosed disease associated with male infertility. However, little is known about the molecules that are involved in its development.
Xin Song, Nan-He Lin, You-Lin Wang, Bin Chen, Hong-Xiang Wang, Kai Hu   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Differential Gene Expression in Vertebrate Embryos [PDF]

Journal of Biological Chemistry, 2009
The invitation to contribute to the Reflections series in the Journal of Biological Chemistry is an honor that I greatly appreciate. It is humbling to find oneself in such distinguished company and a challenge to the literary limitations reflected all too obviously in the scientific writing I usually engage in. What I would like to do is to describe my
openaire   +2 more sources

Predictability of human differential gene expression [PDF]

Proceedings of the National Academy of Sciences, 2019
Differential expression (DE) is commonly used to explore molecular mechanisms of biological conditions. While many studies report significant results between their groups of interest, the degree to which results are specific to the question at hand is not generally assessed, potentially leading to inaccurate interpretation.
Crow, M, Lim, N, Ballouz, S, Pavlidis, P, Gillis, J   +4 more
openaire   +3 more sources

Comparative transcriptome analysis reveals the key role of photosynthetic traits in the formation of differences in photothermal sensitivity in tobacco

BMC Genomics
Background The photothermal sensitivity of tobacco refers to how tobacco plants respond to variations in the photothermal conditions of their growth environment.
Yanfeng Zheng, Qiwei Yu, Anbin Lu, Xiue Chen, Kai Yang, Jingyao Zhang, Ying Huang, Renxiang Liu   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Differential placental gene expression in preeclampsia [PDF]

The FASEB Journal, 2008
Objective: Candidate genes associated with preeclampsia have not been fully described. We conducted a microarray study to investigate global placental gene expression in preeclampsia. Study design: Cases (n=18) and controls (n=18) were selected among patients receiving care at Swedish Medical Center, Seattle, WA.
Daniel A, Enquobahrie, Margaret, Meller, Kenneth, Rice, Bruce M, Psaty, David S, Siscovick, Michelle A, Williams   +5 more
openaire   +2 more sources

Differentially expressed genes.

, 2013
Number of differentially expressed genes after transfection with RUNX2 (red dots), compared to number of genes after permutation of sample labels. Note that values for differentially expressed genes above 150 are shown in brackets.
Martin Kuhlwilm (496658), Armaity Davierwala (496659), Svante Pääbo (2485)   +2 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source