Results 51 to 60 of about 925,682 (298)

diffGEK: differential gene expression kinetics

Bioinformatics
Abstract Motivation A defining characteristic of all metazoan organisms is the existence of different cell states or cell types, driven by changes in gene expression kinetics, principally transcription, splicing and degradation rates.
Melania Barile, Shirom Chabra, Tomoya Isobe, Berthold Gottgens   +3 more
openaire   +1 more source

Differential gene expression during terminal erythroid differentiation

Genomics, 2007
Terminal erythroid differentiation in mammals is the process whereby nucleated precursor cells accumulate erythroid-specific proteins such as hemoglobin, undergo extensive cellular and nuclear remodeling, and ultimately shed their nuclei to form reticulocytes, which then become mature erythrocytes in the circulation.
Koury, S., Yarlagadda, S., Moskalik-Liermo, K., Popli, N., Kim, N., Apolito, C., Peterson, A., Zhang, X., Zu, P., Tamburlin, J., Bofinger, D.   +10 more
openaire   +2 more sources

Hybridization and gene expression: Beyond differentially expressed genes

Molecular Ecology
AbstractGene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Runemark, Anna, Moore, Emily C., Larson, Erica L.   +2 more
openaire   +3 more sources

Predictability of human differential gene expression [PDF]

Proceedings of the National Academy of Sciences, 2019
Differential expression (DE) is commonly used to explore molecular mechanisms of biological conditions. While many studies report significant results between their groups of interest, the degree to which results are specific to the question at hand is not generally assessed, potentially leading to inaccurate interpretation.
Crow, M, Lim, N, Ballouz, S, Pavlidis, P, Gillis, J   +4 more
openaire   +3 more sources

Omics Analysis Revealing Flavonoid Content During Maize Grain Germination

Metabolites
Background/Objectives: The germination process initiates an active process of secondary metabolism, which produces a series of secondary metabolites, including flavonoids. Methods: A metabolomics and transcriptomics analysis was conducted on maize grains
Xiaomin Tian, Lirong Chen, Linlin Sun, Kuijie Gong, Kaichang Liu, Yuqiu Guo   +5 more
doaj   +1 more source

Differential placental gene expression in preeclampsia [PDF]

The FASEB Journal, 2008
Objective: Candidate genes associated with preeclampsia have not been fully described. We conducted a microarray study to investigate global placental gene expression in preeclampsia. Study design: Cases (n=18) and controls (n=18) were selected among patients receiving care at Swedish Medical Center, Seattle, WA.
Daniel A, Enquobahrie, Margaret, Meller, Kenneth, Rice, Bruce M, Psaty, David S, Siscovick, Michelle A, Williams   +5 more
openaire   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Identification and role of differentially expressed genes/proteins between pulmonary tuberculosis patients and controls across lung tissues and blood samples

Immunity, Inflammation and Disease
Background Differentially expressed genes/proteins (DEGs/DEPs) play critical roles in pulmonary tuberculosis (PTB) diagnosis and treatment. However, there is a scarcity of reports on DEGs/DEPs in lung tissues and blood samples in PTB patients.
Qifeng Li, Kuerbanjiang Maierheba
doaj   +1 more source

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies [PDF]

, 2007
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially ...
Brett Thorn, Catalin C. Barbacioru, Cecilie Boysen, Charles Wang, Damir Herman, Ernest S. Kawasaki, Federico M. Goodsaid, Felix W. Frueh, Feng Qian, Hong Fang, Hongmei Sun, Huixiao Hong, James C. Fuscoe, James C. Willey, James J. Chen, Janet A. Warrington, Jie Wu, Jing Han, Lei Guo, Leming Shi, Liang Zhang, Lisa J. Croner, Lu Zhang, Nan Mei, Patrick J. Collins, Qian Xie, Quan-Zhen Li, Raj K. Puri, Richard Shippy, Roderick V. Jensen, Roger G. Perkins, Ron L. Peterson, Russell D. Wolfinger, Shashi Amur, Sheng Zhong, Stephen C. Harris, Sue-Jane Wang, Tzu-Ming Chu, Vincent Bertholet, Weida Tong, Wendell D. Jones, Wenjun Bao, Xiao-hui Fan, Xiaoxi Megan Cao, Xu Guo, Yaron Turpaz, Yongming Andrew Sun, Yuling Luo, Yunqing Ma, Zhenqiang Su   +49 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source