Results 51 to 60 of about 678,844 (309)
Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection
, 2009 Background: Acute aortic dissection (AAD) is a life-threatening condition with high mortality and a relatively unclarified pathophysiological mechanism. Although differentially expressed genes in AAD have been recognized, interactions between these genes
Thorsten Hanke +7 more
core +1 more source
Immunity, Inflammation and DiseaseBackground Differentially expressed genes/proteins (DEGs/DEPs) play critical roles in pulmonary tuberculosis (PTB) diagnosis and treatment. However, there is a scarcity of reports on DEGs/DEPs in lung tissues and blood samples in PTB patients.
Qifeng Li, Kuerbanjiang Maierheba
doaj +1 more source
Omics Analysis Revealing Flavonoid Content During Maize Grain Germination
MetabolitesBackground/Objectives: The germination process initiates an active process of secondary metabolism, which produces a series of secondary metabolites, including flavonoids. Methods: A metabolomics and transcriptomics analysis was conducted on maize grains
Xiaomin Tian +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Differential biclustering for gene expression analysis [PDF]
Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology, 2010 Biclustering algorithms have been successfully used to find subsets of co-expressed genes under subsets of conditions. In some cases, microarray experiments are performed to compare the biological activities of the genes between two classes of cells, such as normal and cancer cells.
Omar Odibat +2 more
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Searching for differentially expressed gene combinations [PDF]
Genome Biology, 2005 AbstractWe propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes.
Dettling, Marcel +2 more
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Differentially expressed genes.
, 2013 Number of differentially expressed genes after transfection with RUNX2 (red dots), compared to number of genes after permutation of sample labels. Note that values for differentially expressed genes above 150 are shown in brackets.
Martin Kuhlwilm (496658) +2 more
core +1 more source