Results 61 to 70 of about 3,651,834 (302)

Differential expression of human interferon genes [PDF]

Nucleic Acids Research, 1984
We developed a method for quantitating closely related mRNAs by S1 mapping and used it to determine the levels of mRNAs for IFN-beta, IFN-gamma and various alpha IFNs (IFN-alpha 1, -alpha 2, -alpha 4, -alpha 5, -alpha 6, -alpha 7, -alpha 8 and -alpha 14) in human peripheral blood leukocytes, lymphoblastoid (Namalwa), HeLa and human fibroblastic cells ...
J, Hiscott, K, Cantell, C, Weissmann
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Differentially expressed genes.

, 2019
Differentially expressed genes.
Catalina García-Castillo (8066531), Carlos Ruíz-Pérez (8066528), Leonardo Posada (8066522), Iván Camilo Acosta (8066525), Alejandro Reyes (771759), Jorge Díaz-Riaño (8066519), María Mercedes Zambrano (8066534)   +6 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection

, 2009
Background: Acute aortic dissection (AAD) is a life-threatening condition with high mortality and a relatively unclarified pathophysiological mechanism. Although differentially expressed genes in AAD have been recognized, interactions between these genes
Thorsten Hanke, Hans H. Sievers, Salah A. Mohamed, Doreen Richardt, Gazanfer Belge, Joern Bullerdiek, Efstratios I. Charitos, Claudia Schmidtke   +7 more
core   +1 more source

Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots

International Journal of Nanomedicine, 2020
Yanjie Yang, Peisen Li, Yao Lin, Ziqi Li, Tianyi Cui, Zhenhua Song, Weixia Wu, Shuangyu Lv, Shaoping Ji Henan Provincial Engineering Centre for Tumor Molecular Medicine, Institute of Molecular Medicine, School of Basic Medical Sciences, Henan University,
Yang Y, Li P, Lin Y, Li Z, Cui T, Song Z, Wu W, Lv S, Ji S   +8 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

diffGEK: differential gene expression kinetics

Bioinformatics
Abstract Motivation A defining characteristic of all metazoan organisms is the existence of different cell states or cell types, driven by changes in gene expression kinetics, principally transcription, splicing and degradation rates.
Melania Barile, Shirom Chabra, Tomoya Isobe, Berthold Gottgens   +3 more
openaire   +2 more sources

Gene Expression Profiling of African Bermudagrass under Cold Acclimation

HortScience
African bermudagrass (Cynodon transvaalensis Burtt Davy) is a fine-texture warm-season grass that often crosses with common bermudagrass [C. dactylon (L.) Pers] to create turf-type hybrid bermudagrass.
Felipe Cevallos, Mingying Xiang, Xiaoyu Zhang, Yanqi Wu, Justin Moss, Charles Fontanier, Dennis Martin, Shuhao Yu   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source