Results 81 to 90 of about 925,682 (298)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots

International Journal of Nanomedicine, 2020
Yanjie Yang, Peisen Li, Yao Lin, Ziqi Li, Tianyi Cui, Zhenhua Song, Weixia Wu, Shuangyu Lv, Shaoping Ji Henan Provincial Engineering Centre for Tumor Molecular Medicine, Institute of Molecular Medicine, School of Basic Medical Sciences, Henan University,
Yang Y, Li P, Lin Y, Li Z, Cui T, Song Z, Wu W, Lv S, Ji S   +8 more
doaj  

Does Logarithm Transformation of Microarray Data Affect Ranking Order of Differentially Expressed Genes?

, 2006
A common practice in microarray analysis is to transform the microarray raw data (light intensity) by a logarithmic transformation, and the justification for this transformation is to make the distribution more symmetric and Gaussian-like.
Li, Wentian, Suh, Young Ju, Zhang, Jingshan   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Gene Expression Profiling of African Bermudagrass under Cold Acclimation

HortScience
African bermudagrass (Cynodon transvaalensis Burtt Davy) is a fine-texture warm-season grass that often crosses with common bermudagrass [C. dactylon (L.) Pers] to create turf-type hybrid bermudagrass.
Felipe Cevallos, Mingying Xiang, Xiaoyu Zhang, Yanqi Wu, Justin Moss, Charles Fontanier, Dennis Martin, Shuhao Yu   +7 more
doaj   +1 more source

Intersex goats show different gene expression levels in the hypothalamus and pituitary compared with non‐intersex goats based on RNA‐Seq

Veterinary Medicine and Science, 2022
The conditions for sex reversal in vertebrate species have been extensively studied, and the results highlighted numerous key factors involved in sex differentiation.
Haoyuan Han, Shuai Yang, Jun Li, Jinyan Zhao, Hongfang Wei, Si Ha, Wantao Li, Congcong Li, Kai Quan   +8 more
doaj   +1 more source

The multiple ADP/ATP translocase genes are differentially expressed during human muscle development [PDF]

, 1992
The expression of the genes encoding the three isoforms of the human ADP/ATP translocase (T1, T2, and T3) has been analyzed at different stages of myogenic differentiation in an in vitro muscle cell system and compared with that in mature muscle.
Attardi, Giuseppe, Engel, W. King, Hurko, Orest, Lunardi, Joël   +3 more
core  

Differential Gene Expression in Vertebrate Embryos [PDF]

Journal of Biological Chemistry, 2009
The invitation to contribute to the Reflections series in the Journal of Biological Chemistry is an honor that I greatly appreciate. It is humbling to find oneself in such distinguished company and a challenge to the literary limitations reflected all too obviously in the scientific writing I usually engage in. What I would like to do is to describe my
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source