Results 91 to 100 of about 103,599 (300)
Enhancers, enhancers - from their discovery to today's universe of transcription enhancers [PDF]
, 2015 Transcriptional enhancers are short (200-1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene.
Schaffner, Walter
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
EFSA Journal, 2010 The additive Danisco® Glycosidase TPT/L is an enzyme preparation containing endo‐1, 4‐beta‐xylanase produced by a genetically modified strain of Trichoderma reesei and endo‐1, 3(4)‐beta‐glucanase produced by another strain of Trichoderma reesei.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
PolymersThe increasing production of bioplastics worldwide requires sustainable end-of-life solutions to minimize the environmental burden. Anaerobic digestion (AD) has been recognized as a potential technology for valorizing waste and producing renewable energy.
Mohamed Shafana Farveen +3 more
openaire +2 more sources
Comparison of CoRE-ATAC and ChromHMM cell-specific enhancers.
, 2021 Overlap of CoRE-ATAC andChromHMM cell-specific enhancers. CoRE-ATAC predictions significantly overlap ChromHMM enhancers for all cell types (P-Values (TIF)
Asa Thibodeau (3164796) +5 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
, 2021 Coordinates of the identified poised enhancers (genome assembly mm10). (XLSX)
Alexandra Santanach (11379032) +6 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Safety and efficacy of OPTIPHOS® (6‐phytase) as a feed additive for finfish
EFSA Journal, 2017 The additive OPTIPHOS® is a preparation of 6‐phytase that is authorised for use in avian species, weaned piglets, pigs for fattening and sows. The applicant seeks for an extension of use of the product to finfish, at a dose range between 250 and 1,000 ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +24 more
doaj +1 more source