Results 101 to 110 of about 1,512 (303)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Debaryomyces hansenii Strains from Traditional Chinese Dry-Cured Ham as Good Aroma Enhancers in Fermented Sausage

open access: yes
In some countries, yeasts are still not allowed in the production of commercially fermented sausages. Therefore, further research is needed on producing fermented meat products using different strains of yeasts. In this study, two strains of Debaryomyces
Xiaoying Yang, Shan Xiao, Jihui Wang
core   +1 more source

Safety and efficacy of OPTIPHOS® (6‐phytase) as a feed additive for finfish

open access: yesEFSA Journal, 2017
The additive OPTIPHOS® is a preparation of 6‐phytase that is authorised for use in avian species, weaned piglets, pigs for fattening and sows. The applicant seeks for an extension of use of the product to finfish, at a dose range between 250 and 1,000 ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)   +24 more
doaj   +1 more source

Enhancing Bioplastic Degradation in Anaerobic Digestion: A Review of Pretreatment and Co-Digestion Strategies

open access: yesPolymers
The increasing production of bioplastics worldwide requires sustainable end-of-life solutions to minimize the environmental burden. Anaerobic digestion (AD) has been recognized as a potential technology for valorizing waste and producing renewable energy.
Mohamed Shafana Farveen   +3 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of Axtra (R) PHY 15 000 L (6-phytase) as a feed additive for poultry and porcine species [PDF]

open access: yes, 2015
The additive Axtra (R) PHY 15 000 L is a liquid preparation of 6-phytase produced by a genetically modified strain of Trichoderma reesei. This product is intended for use as a zootechnical additive, functional group of digestibility enhancers, in feed ...
Georges Bories   +18 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Safety and efficacy of APSA PHYTAFEED® 20,000 GR/L (6‐phytase) as a feed additive for piglets (suckling and weaned) and growing minor porcine species

open access: yesEFSA Journal, 2019
Following a request from the European Commission, the EFSA Panel on Additives and products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of APSA PHYTAFEED® 20,000 GR/L (6‐phytase) as a ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)   +23 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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