Results 71 to 80 of about 3,272 (311)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Safety and efficacy of RONOZYME® WX CT/L (endo‐1,4‐β‐xylanase) as a feed additive for sows for reproduction

EFSA Journal, 2019
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of RONOZYME® WX CT/L as a feed additive for sows for ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Elisa Pettenati, Montserrat Anguita   +19 more
doaj   +1 more source

Digestibility of resistant starch containing preparations using two in vitro models [PDF]

, 2018
Background: Resistant starch (RS) is known for potential health benefits in the human colon. To investigate these positive effects it is important to be able to predict the amount, and the structure of starch reaching the large intestine.
Amadò, Renato, Arrigoni, Eva, Brouns, Fred, Fässler, Caroline, Hafner, Valeria, Venema, Koen   +5 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of Kemzyme® Plus Dry (endo‐1,3(4)‐beta‐glucanase, endo‐1,4‐beta‐glucanase, alpha‐amylase, bacillolysin and endo‐1,4‐beta‐xylanase) for poultry, ornamental birds and piglets (weaned)

EFSA Journal, 2015
Kemzyme® Plus Dry is a preparation of four glycosyl hydrolases and a protease which is to be used as a feed additive for poultry, ornamental birds and weaned piglets.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Bioinformatic analyses of the structural and functional complexity in chromosomal interactomes [PDF]

, 2015
Evolution requires information storage systems with different demands with respect to persistence. While the genome provides a mechanism for long term, static and accurate information storage, it is incapable of mediating adaptation to short term ...
Fernandez Woodbridge, Alejandro
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Safety and efficacy of Natugrain® TS/TS L (endo‐1,4‐beta‐xylanase and endo‐1,4‐beta‐glucanase) as a feed additive for sows

EFSA Journal, 2020
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Natugrain® TS/TS L.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Kos Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Noël Albert Dierick, Guido Rychen, Montserrat Anguita   +20 more
doaj   +1 more source

Scientific Opinion on the safety and efficacy of Feedlyve AXC (endo-1,4-beta-xylanase) as a feed additive for turkeys [PDF]

EFSA Journal, 2012
<p>Feedlyve AXC is an enzyme preparation containing an endo-1,4-beta-xylanase produced by a non-genetically modified strain of <em>Trichoderma koningii</em>. The additive is intended for use in turkeys and is presented in several forms.
EFSA Panel on Additives and Products or Substances used in Animal Feed
doaj   +1 more source

Development and storage characteristics of shrimp (Solenocera crassicornis) based snack food using extrusion technology [PDF]

, 2016
An attempt was made to develop nutrient rich extruded snacks from lesser utilized protein rich shrimp (Solenocera crassicornis) flour using twin screw extruder. The extruded were in order to fried and packed in to High Density Polyethelene (HDPE).
Baraiya, K. G., Jha, A. K., Kadri, R. M., Khileri, R. A., Lende, S. R., Mulye, V. B., Patel, M.R., Zofair, S. M.   +7 more
core   +2 more sources