Results 81 to 90 of about 3,272 (311)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of Safizym^® X (endo-1,4-beta-xylanase) as a feed additive for chickens and turkeys for fattening and laying hens [PDF]

EFSA Journal, 2014
Safizym® X is an enzyme preparation of endo-1,4-beta-xylanase produced by a non-genetically modified strain of Trichoderma reesei which is presented in solid and liquid forms.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Phytase: application in food industry [PDF]

, 2010
Phytates have been considered as a threat in human diet due to its antinutrients behaviour which known as strong chelators of divalent minerals such as Ca²+, Mg²+, Zn²+ and Fe²+.
Abd. Manap, Mohd. Yazid, Meor Hussin, Anis Shobirin, Mustafa, Shuhaimi, Suhairin, Afinah   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Scientific Opinion on the safety and efficacy of AGal‐Pro BL‐L (alpha‐galactosidase and endo‐1, 4‐beta‐glucanase) as a feed additive for chickens for fattening

EFSA Journal, 2014
The additive AGal‐Pro BL‐L is a liquid preparation of alpha‐galactosidase produced by a genetically modified strain of Saccharomyces cerevisiae and of endo‐1, 4‐beta‐glucanase produced by a non‐genetically modified strain of Aspergillus niger.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Lyotropic Liquid Crystalline Phases for the Formulation of Future Functional Foods [PDF]

, 2016
The especial features and advanced characteristics of Lyotropic Liquid Crystalline (LLC) phases as potent nano materials for encapsulation and the development of novel delivery systems for nutraceuticals and other bioactive compounds are reviewed ...
Rappolt, M, Sadeghpour, A
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Safety and efficacy of APSA PHYTAFEED® 20,000 GR/L (6‐phytase) as a feed additive for chickens for fattening, chickens reared for laying and minor growing poultry species

EFSA Journal, 2019
APSA PHYTAFEED® 20,000 GR/L is a preparation of 6‐phytase which is presented in solid and liquid forms. This additive is intended to be used as a zootechnical additive in chickens for fattening or reared for laying/breeding and minor poultry species for ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Lieve Herman, Boet Glandorf, Maria Saarela, Montserrat Anguita   +21 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Alternative uses for co-products: Harnessing the potential of valuable compounds from meat processing chains [PDF]

, 2017
peer-reviewedOpportunities for exploiting the inherent value of protein-rich meat processing co-products, in the context of increased global demand for protein and for sustainable processing systems, are discussed. While direct consumption maybe the most
Abbah, Abu-Akkada, Agyei, Al-Shawaf, Anne Maria Mullen, Arihara, Bah, Bhaskar, Boskot, Boutinguiza, Browne, Bruckner, Calvo, Carlos Álvarez, Chandrapala, Choi, Choi, Collagen market, Corbin, Cramer, Datamonitor, Dewitt, Di Bernardini, Di Bernardini, Dimitrios I. Zeugolis, EC Directive 2008/1/EC concerning integrated pollution prevention and control, EC Directive 2008/98/EC on waste and repealing certain Directives, EC Regulation 1069/2009, EC Regulation 1169/2011, EC Regulation 1333/2008, EC Regulation 609/2013, EC Regulation 853/2004, EC Regulation 999/2001, Eileen O'Neill, Escudero, Fallas, FAO, Ferraro, Fichard, Frewer, Frischholz, Fu, Galanakis, Galanakis, Garde-Cerdán, Gauba, Glanbia.com, Global Market Insights report, Gómez-Guillén, Heinz, Henchion, Hettiarachchy, Hickey, Hoffmann, Hsieh, Hurtado, Jayathilakan, Kadam, Kielty, Korhonen, Korhonen, Kotch, Kumar, Lee, Lemes, Leoci, Li, Liana Drummond, Linder, Looy, Lynch, Lynn, López, Maeve Henchion, Marcet, Marti, Martins, Millward, Montero Castillo, Mullen, Mullen, Murray, Myllyharju, O'Leary, O'Leary, O'Sullivan, Ofori, Olsen, Pares, Pimentel, Power, Rele, Rivera, Rozin, Rutschmann, Ryan, Sarmadi, Satyam, Satyam, Schmidt, Selmane, Sharma, Smeller, Soliva-Fortuny, Steen, Stein, Sun, Thomas, Toldra, Toldrá, Toman, Tomita, Trostle, USDA-FSIS, USDA-FSIS Directive 7120.1, Van, Van Huis, Venegas Fornias, Vernooij, Vuorela, Waldron, Williams, Wilson, World Health Organization, Zeugolis, Zeugolis, Zhang, Zou, Álvarez   +128 more
core   +1 more source