Results 61 to 70 of about 23,495,921 (382)
Frontiers in Immunology, 2023 ObjectiveOur study represents the first meta-analysis conducted to evaluate the prognostic utility of the baseline prognostic nutritional index (PNI) in patients with gastrointestinal cancer (GIC) who received immune checkpoint inhibitor (ICI) therapy ...
Lilong Zhang +13 more
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Chinese Medical JournalBackground: Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on the burden of digestive system diseases in China are lacking.
Zhi-Yuan Cheng +10 more
semanticscholar +1 more source
Archives of Pathology & Laboratory Medicine, 2020 CONTEXT.— The 5th edition of the World Health Organization classification of digestive system tumors discusses several advancements and developments in understanding the etiology, pathogenesis, and diagnosis of several digestive tract tumors. OBJECTIVE.
N. Assarzadegan, E. Montgomery
semanticscholar +1 more source
Role of Leptin in the Digestive System
Frontiers in Pharmacology, 2021 Leptin is a pluripotent peptide hormone produced mainly by adipocytes, as well as by other tissues such as the stomach. Leptin primarily acts on the central nervous system, particularly the hypothalamus, where this hormone regulates energy homeostasis ...
Min-Hyun Kim, Hyeyoung Kim
semanticscholar +1 more source
Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review
Frontiers in Oncology, 2022 Chimeric antigen receptor (CAR) -T cell therapy has become one of the hot topics in tumor immunity research in recent years. Although CAR-T cell therapy is highly effective in treating hematological malignancies, there are numerous obstacles that prevent
Lele Miao +14 more
doaj +1 more source
Plant cell walls: impact on nutrient bioaccessibility and digestibility [PDF]
, 2020 Cell walls are important structural components of plants, affecting both the bioaccessibility and subsequent digestibility of the nutrients that plant-based foods contain.
Edwards, Cathrina H. +3 more
core +3 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms
Cell Death and Disease, 2021 A circRNA is a type of endogenous noncoding RNA that consists of a closed circular RNA molecule formed by reverse splicing; these RNAs are widely distributed in a variety of biological cells. In contrast to linear RNAs, circRNAs have no 5′ cap or 3′ poly(
Jie Li +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
Systematic Reviews, 2022 Background and objectives Cancer morbidity and mortality rates remain high, and thus, at present, considerable efforts are focused on finding drugs with higher sensitivity against tumor cells and fewer side effects. Disulfiram (DSF), as an anti-alcoholic
Ling Wang +4 more
doaj +1 more source