Results 71 to 80 of about 1,487,193 (321)

Early Detection of Oncological Diseases of the Digestive System (Guidelines of the Russian Gastroenterological Association and the Russian Association of Oncologists for Primary Care Physicians)

Russian Journal of Gastroenterology Hepatology Coloproctology, 2019
Aim. The present guidelines intended for primary care physicians are aimed at facilitating early diagnosis of malignant tumours of the digestive system, which can significantly improve the immediate and long-term results of their treatment.General ...
V. T. Ivashkin, I. V. Mayev, A. Kaprin, M. Yu. Agapov, D. N. Andreev, A. S. Vodoleev, M. Zharkova, M. P. Korolev, Yu. A. Kucheryavyi, T. Lapina, M. V. Mayevskaya, A. Okhlobystin, Ch. S. Pavlov, A. V. Paraskevova, S. S. Pirogov, E. Poluektova, D. Rumyantseva, A. Trukhmanov, P. Tsarkov, A. Sheptulin, O. S. Shifrin   +20 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Diseases of the Digestive System and Air Pollution

The International Annals of Medicine, 2018
Aim: The aim of this work is to study the diseases of the human digestive system in Cyprus and their relationship to smoking and air pollution. Methods: The statistical methods were used to derive the results of this work are Student t-test in order to check the statistical significance of digestive diseases in relation to gender, One-Way ANOVA test ...
Irene Rethemiotaki, Andrew Rethemiotakis
openaire   +2 more sources

Characteristics of malignant tumors of digestive system and autoimmune diseases

Frontiers in Genetics, 2023
With the development of preoperative examination technology, endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNA) has been widely used in preoperative pathological diagnosis. However, challenges remain in obtaining appropriate tissue samples and obtaining accurate pathological results to predict disease risk.
Hang Yin, Qun Li
openaire   +3 more sources

A retrospective analysis of the prevalence of dental diseases in patients with digestive system cancers

Medicine, 2019
The relationship between dental diseases and the prevalence of digestive system cancers remains unclear. The aim of the present study was to examine the prevalence of dental diseases in patients treated for digestive system cancers.
H. Sakai, S. Yamada, T. Gibo, Nobuhiko Yoshimura, F. Nishimaki, E. Kondo, T. Kamata, H. Kurita   +7 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Quality of life in patients with ileal pouch for ulcerative colitis

Journal of Coloproctology, 2013
Introduction: proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard surgical procedure for the treatment of ulcerative colitis (UC) and is associated with the prospect of cure.
Marcela Soares Gonçalves de Tilio, Larissa Berbert Arias, Michel Gardere Camargo, Priscila Sene Portel de Oliveira, Nathalia Vieira Panzetti, Maria de Lourdes Setsuko Ayrizono, Raquel Franco Leal, João José Fagundes, Claudio Saddy Rodrigues Coy   +8 more
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Years of Life Lost due to Diseases of the Digestive System in Poland in 2000-2014.

Journal of Gastrointestinal and Liver Diseases, 2018
BACKGROUND AND AIMS Diseases of the digestive system substantially contribute to premature mortality of the Polish population. Years of Life Lost (YLLs) are more and more commonly used in order to evaluate social and economic aspects of these deaths. The
Paulina Paciej-Gołębiowska, M. Pikala, I. Maniecka-Bryła   +2 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source