Results 21 to 30 of about 207,794 (266)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Macrophage inhibitory cytokine 1, syncollin and thrombospondin-2 in pancreatic ductal adenocarcinoma and chronic pancreatitis differentiation

Frontiers in Oncology
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a rising global incidence. Differentiating PDAC from non-malignant pancreatic conditions, particularly chronic pancreatitis (CP), remains challenging due to ...
Michalina Wieczorek, Lukasz Wieczorek, Anna Borkowska, Ewa Malecka-Wojciesko   +3 more
doaj   +1 more source

Procoagulant Disorders in Patients with Newly Diagnosed Pancreatic Adenocarcinoma

Medicina, 2020
Background and objectives: Cancer coagulopathy is thought to be partially due to the up-regulation of tissue factor (TF), thrombin-antithrombin complex (TAT) and soluble P-selectin (sP-selectin).
Renata Talar-Wojnarowska, Małgorzata Woźniak, Anna Borkowska, Katarzyna Cypryk, Marek Olakowski, Ewa Małecka-Panas   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Clinical Outcomes of Patients with Colorectal Cancer Who Underwent Comprehensive Genomic Profiling: A Single-institution Non-comparative Prospective Observational Study

Journal of the Anus, Rectum and Colon
Objectives: Although some studies have evaluated the effectiveness of comprehensive genomic profiling (CGP) in solid tumors, the effectiveness of CGP in metastatic colorectal cancer (mCRC) has not been evaluated using detailed real-world long-outcome ...
Yoshiko Mori, Okihide Suzuki, Noriko Tanabe, Aoi Sugino, Takehiro Shiraishi, Norimichi Chiyonobu, Kenichi Chikatani, Noriyasu Chika, Satoshi Hatano, Takatoshi Matsuyama, Keiichiro Ishibashi, Hideyuki Ishida   +11 more
doaj   +1 more source

Digestive Tract

, 2023
AbstractNuclear medicine studies can evaluate functional abnormalities of the digestive tract in children. Repeat episodes of gastroesophageal reflux (GER) are associated with clinical gastrointestinal and/or respiratory manifestations of variable severity. GER scintigraphy, the “milk scan,” can detect GER and aspiration. Clinical signs and symptoms of
Anita Brink, Lorenzo Biassoni, Zvi Bar-Sever   +2 more
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet

Foods
Background: Celiac disease (CD) is a chronic, permanent, gluten-dependent disease that manifests itself with inflammation of the small intestine and malabsorption in genetically predisposed individuals with HLA-DQ2 and -DQ8 (human leukocyte antigen ...
Marek K. Kowalski, Danuta Domżał-Magrowska, Ewa Małecka-Wojciesko   +2 more
doaj   +1 more source

Pythiosis of the digestive tract in sheep [PDF]

Journal of Veterinary Diagnostic Investigation, 2012
Cutaneous and rhinofacial infections by Pythium insidiosum have previously been reported in sheep in Brazil. In the current study, a new form of pythiosis involving the alimentary tract of 2 nursing lambs from 2 different farms in the semiarid region of Brazil is described.
Clarice R M, Pessoa, Franklin, Riet-Correa, Luciano A, Pimentel, Felício, Garino, Antônio F M, Dantas, Glaucia D, Kommers, Ivon M, Tabosa, Janildo L, Reis-Júnior   +7 more
openaire   +2 more sources