Results 31 to 40 of about 529,746 (253)

Macrophage inhibitory cytokine 1, syncollin and thrombospondin-2 in pancreatic ductal adenocarcinoma and chronic pancreatitis differentiation

Frontiers in Oncology
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a rising global incidence. Differentiating PDAC from non-malignant pancreatic conditions, particularly chronic pancreatitis (CP), remains challenging due to ...
Michalina Wieczorek, Lukasz Wieczorek, Anna Borkowska, Ewa Malecka-Wojciesko   +3 more
doaj   +1 more source

A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (the SuDDICU study) [PDF]

, 2010
Peer ...
Campbell, MK, L MacIntyre, Seppelt I, Cuthbertson BH, J Francis, Grimshaw, J. M., MacIntyre L, BH Cuthbertson, Macintyre, L., Grimshaw, J, Seppelt, I., I Seppelt, Cuthbertson, B H, Francis, J., MacIntyre, L, Francis J, Campbell, M K, Cuthbertson, B. H., Campbell MK, Campbell, M. K., null null, Cuthbertson, BH, J Grimshaw, Seppelt, I, Francis, J, MK Campbell, Grimshaw J, SuDDICU study groups   +27 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Clinical Outcomes of Patients with Colorectal Cancer Who Underwent Comprehensive Genomic Profiling: A Single-institution Non-comparative Prospective Observational Study

Journal of the Anus, Rectum and Colon
Objectives: Although some studies have evaluated the effectiveness of comprehensive genomic profiling (CGP) in solid tumors, the effectiveness of CGP in metastatic colorectal cancer (mCRC) has not been evaluated using detailed real-world long-outcome ...
Yoshiko Mori, Okihide Suzuki, Noriko Tanabe, Aoi Sugino, Takehiro Shiraishi, Norimichi Chiyonobu, Kenichi Chikatani, Noriyasu Chika, Satoshi Hatano, Takatoshi Matsuyama, Keiichiro Ishibashi, Hideyuki Ishida   +11 more
doaj   +1 more source

Procoagulant Disorders in Patients with Newly Diagnosed Pancreatic Adenocarcinoma

Medicina, 2020
Background and objectives: Cancer coagulopathy is thought to be partially due to the up-regulation of tissue factor (TF), thrombin-antithrombin complex (TAT) and soluble P-selectin (sP-selectin).
Renata Talar-Wojnarowska, Małgorzata Woźniak, Anna Borkowska, Katarzyna Cypryk, Marek Olakowski, Ewa Małecka-Panas   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The host genotype affects the bacterial community in the human gastrointestinal tract [PDF]

, 2001
The gastrointestinal (GI) tract is one of the most complex ecosystems consisting of microbial and host cells. It is suggested that the host genotype, the physiology of the host and environmental factors affect the composition and function of the ...
Vos, W.M., de, Visser, J.A.G.M., de, Zoetendal, E.G., Akkermans, A.D.L., Akkermans-van Vliet, W.M.   +4 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet

Foods
Background: Celiac disease (CD) is a chronic, permanent, gluten-dependent disease that manifests itself with inflammation of the small intestine and malabsorption in genetically predisposed individuals with HLA-DQ2 and -DQ8 (human leukocyte antigen ...
Marek K. Kowalski, Danuta Domżał-Magrowska, Ewa Małecka-Wojciesko   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source