Results 31 to 40 of about 2,148,046 (305)

Optimization and Tradespace Analysis of a Classic Machine—A Street Clock Movement Study

Machines
Computer-based engineering design tools can quicken the cadence for machine design, which enables companies to compete better in the global marketplace.
Pranav Manvi, Yifan Xu, David Moline, Cameron Turner, John Wagner   +4 more
doaj   +1 more source

Analysis of formation methods of graphic competence of future engineering teachers

Journal of Education, Health and Sport, 2022
The article substantiates the need to improve the formation methods of graphic competence of future engineering teachers by means of digital technologies.
P. Koliasa
doaj   +1 more source

Coordination and control in project-based work: digital objects and infrastructures for delivery [PDF]

, 2010
A major infrastructure project is used to investigate the role of digital objects in the coordination of engineering design work. From a practice-based perspective, research emphasizes objects as important in enabling cooperative knowledge work and ...
Lobo, Sunila, Whyte, Jennifer
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Soft Robot Design, Manufacturing, and Operation Challenges: A Review

Journal of Manufacturing and Materials Processing
Advancements in smart manufacturing have embraced the adoption of soft robots for improved productivity, flexibility, and automation as well as safety in smart factories.
Getachew Ambaye, Enkhsaikhan Boldsaikhan, Krishna Krishnan   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Digital Engineering: a Case Study in an Irish Consultancy Practice

Journal of Sustainable Design and Applied Research in Innovative Engineering of the Built Environment, 2019
The building services engineering (BSE) industry has wrestled with its productivity gap for many years and the time has come to embrace innovation. Its practitioners now have the key to unlock the future by the smart use of technology, which has the ...
Raymond Reilly
doaj   +1 more source

DIDET: Digital libraries for distributed, innovative design education and teamwork. Final project report [PDF]

, 2008
The central goal of the DIDET Project was to enhance student learning opportunities by enabling them to partake in global, team based design engineering projects, in which they directly experience different cultural contexts and access a variety of ...
Breslin, C., Grierson, H., JISC (Joint Information Systems Committee)   +2 more
core  

User Guided Design: Building Confidence in Engineering Data Publication [PDF]

, 2016
Advances in imaging technology have generated large volumetric datasets in the field of petroleum engineering. To address the need to share this data, a multidisciplinary team developed the Digital Rocks Portal.
Esteva, Maria, Prodanović, Maša, Ranganath, Aditi, Sweat, Sandra   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source