Results 31 to 40 of about 39,597,201 (297)

A performance estimation method of Loop Heat Pipe with a wick permeability model considering dry-out of wick pores

Nihon Kikai Gakkai ronbunshu, 2014
In this paper, we propose a practical simulation method for designing Loop Heat Pipe (LHP) which is applied to cooling system for electronic devices. To realize rapid evaluation of cooling performance of LHP, the proposed performance estimation method ...
Izumi NITTA, Sachio KOBAYASHI, Hiroki KOBAYASHI, Masayoshi HASHIMA, Yuichi SATO, Susumu OGATA, Takahiro KIMURA   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Digital Engineering: a Case Study in an Irish Consultancy Practice

Journal of Sustainable Design and Applied Research in Innovative Engineering of the Built Environment, 2019
The building services engineering (BSE) industry has wrestled with its productivity gap for many years and the time has come to embrace innovation. Its practitioners now have the key to unlock the future by the smart use of technology, which has the ...
Raymond Reilly
doaj   +1 more source

Digital Addiction: A Requirements Engineering Perspective [PDF]

, 2014
[Context and motivation] Digital Addiction, (hereafter referred to as DA), has become a serious issue that has a diversity of socio-economic side effects. [Question/problem] In spite of its high importance, DA got little recognition or guidance as to how software en- gineering should take it into account.
Amen Alrobai, Keith Phalp, Raian Ali
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Analysis of formation methods of graphic competence of future engineering teachers

Journal of Education, Health and Sport, 2022
The article substantiates the need to improve the formation methods of graphic competence of future engineering teachers by means of digital technologies.
P. Koliasa
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Specifying Simulation Commitments Early in System Design: Introduction to the EFSUT Methodology

Systems
Engineering programs increasingly rely on simulation for early design decisions, yet a simulation’s obligations—the specific questions it must answer and observations it must provide—are often left implicit until late in development.
Bernard P. Zeigler
doaj   +1 more source