Results 41 to 50 of about 39,597,201 (297)

Tutorials for Integrating CAD/CAM in Engineering Curricula

Education Sciences, 2018
This article addresses the issue of educating engineering students with the knowledge and skills of Computer-Aided Design and Manufacturing (CAD/CAM). In particular, three carefully designed tutorials—cutting tool offsetting, tool-path generation ...
AMM Sharif Ullah, Khalifa H. Harib
doaj   +1 more source

Requirements Engineering: Best Practice [PDF]

, 2014
Many software solutions have failed because they did not meet stakeholder needs. In response to this problem a massive amount of techniques were de-veloped to elicit stakeholder needs, to analyze the implications of these needs on the software, to ...
Zwingli, Adrian, Grau, Rainer, Rainer Grau, Fricker, Samuel, Samuel A. Fricker, Adrian Zwingli   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Three-Pronged Verification Approach to Higher-Level Verification Using Graph Data Structures

Systems
Individual model verification is a common practice that increases the quality of design on the left side of the Vee model, often before costly builds and prototypes are implemented.
Daniel Dunbar, Thomas Hagedorn, Mark Blackburn, Dinesh Verma   +3 more
doaj   +1 more source

Comparison of Bayesian Networks, G-estimation and linear models to estimate causal treatment effects in aggregated N-of-1 trials with carry-over effects

BMC Medical Research Methodology, 2023
Background The aggregation of a series of N-of-1 trials presents an innovative and efficient study design, as an alternative to traditional randomized clinical trials.
Thomas Gärtner, Juliana Schneider, Bert Arnrich, Stefan Konigorski   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Test and Evaluation of AI/ML Enhanced Digital Twin

Systems
A Digital Twin (DT) is not just a collection of static digital models at the component level of a physical system, but a dynamic entity that evolves in parallel with the physical system it mirrors.
Mario Reyes Garcia, Jesus Castillo, Afroza Shirin   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Industry Based Adaptive Educational Programs

Высшее образование в России, 2019
The aim of this work is to summarize the experience in the development and implementation of industry-oriented educational programs in the field of digital engineering in the educational process.The article presents an example of the interaction of the ...
M. G. Ganchenkova, O. V. Boyko
doaj   +1 more source