Results 51 to 60 of about 2,148,046 (305)

A Three-Pronged Verification Approach to Higher-Level Verification Using Graph Data Structures

Systems
Individual model verification is a common practice that increases the quality of design on the left side of the Vee model, often before costly builds and prototypes are implemented.
Daniel Dunbar, Thomas Hagedorn, Mark Blackburn, Dinesh Verma   +3 more
doaj   +1 more source

Comparison of Bayesian Networks, G-estimation and linear models to estimate causal treatment effects in aggregated N-of-1 trials with carry-over effects

BMC Medical Research Methodology, 2023
Background The aggregation of a series of N-of-1 trials presents an innovative and efficient study design, as an alternative to traditional randomized clinical trials.
Thomas Gärtner, Juliana Schneider, Bert Arnrich, Stefan Konigorski   +3 more
doaj   +1 more source

Assessing digital preservation frameworks: the approach of the SHAMAN project [PDF]

, 2009
How can we deliver infrastructure capable of supporting the preservation of digital objects, as well as the services that can be applied to those digital objects, in ways that future unknown systems will understand?
Elena, M., Innocenti, P., Ludwig, J., Pempe, W., Ross, S., Wilson, T.   +5 more
core   +1 more source

We Could, but Should We? Ethical Considerations for Providing Access to GeoCities and Other Historical Digital Collections [PDF]

, 2020
We live in an era in which the ways that we can make sense of our past are evolving as more artifacts from that past become digital. At the same time, the responsibilities of traditional gatekeepers who have negotiated the ethics of historical data ...
Bastian M., Cohen D., Dent P., Frankel C., Hallinan B., Jenkins H., Klein E., Lin J., McTavish S., Milligan I., Milligan I., Smith M.   +11 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Test and Evaluation of AI/ML Enhanced Digital Twin

Systems
A Digital Twin (DT) is not just a collection of static digital models at the component level of a physical system, but a dynamic entity that evolves in parallel with the physical system it mirrors.
Mario Reyes Garcia, Jesus Castillo, Afroza Shirin   +2 more
doaj   +1 more source

Economics and Engineering for Preserving Digital Content [PDF]

, 2007
Progress towards practical long-term preservation seems to be stalled. Preservationists cannot afford specially developed technology, but must exploit what is created for the marketplace.
Gladney, Dr. H. M.
core   +1 more source

A method to Formalise the Rapid Prototyping Process [PDF]

, 1999
Facing the increasing complexity of the product design area, (reduction of cycle times, introduction of simultaneous engineering, introduction of digital mock-up, ... ) a research department which wants to define a rapid prototyping process is confronted
AOUSSAT, Améziane, DUBOIS, Patrice, LE COQ, Marc   +2 more
core   +6 more sources

Verification, Analytical Validation, and Clinical Validation (V3): The Foundation of Determining Fit-for-Purpose for Biometric Monitoring Technologies (BioMeTs) [PDF]

, 2020
Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, ethics, patient advocacy, and healthcare policy, to name a few.
Bakker, Jessie, Bent, Brinnae, Coravos, Andrea, Dowling, Ariel, Fitzer-Attas, Cheryl, Godfrey, Alan, Godino, Job, Goldsack, Jennifer, Gujar, Ninad, Ismailova, Elena, Manta, Christine, Peterson, Barry, Vandendriessche, Benjamin, Wang, Ke, Wood, William   +14 more
core   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source