Results 51 to 60 of about 978,255 (310)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Vendor partnerships with engineering libraries partnering with Knovel : case studies in information outreach [PDF]

, 2005
The engineering library plays a critical role in initiating and maintaining the conduit between vendors of engineering information and the users of that information—faculty, students, and researchers.
Van Epps, Amy S., Dunn, Lisa, Dunn, Lisa G., Paulsen, W. Charles, Bhatt, Jay   +4 more
core  

A Three-Pronged Verification Approach to Higher-Level Verification Using Graph Data Structures

Systems
Individual model verification is a common practice that increases the quality of design on the left side of the Vee model, often before costly builds and prototypes are implemented.
Daniel Dunbar, Thomas Hagedorn, Mark Blackburn, Dinesh Verma   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Test and Evaluation of AI/ML Enhanced Digital Twin

Systems
A Digital Twin (DT) is not just a collection of static digital models at the component level of a physical system, but a dynamic entity that evolves in parallel with the physical system it mirrors.
Mario Reyes Garcia, Jesus Castillo, Afroza Shirin   +2 more
doaj   +1 more source

Comparison of Bayesian Networks, G-estimation and linear models to estimate causal treatment effects in aggregated N-of-1 trials with carry-over effects

BMC Medical Research Methodology, 2023
Background The aggregation of a series of N-of-1 trials presents an innovative and efficient study design, as an alternative to traditional randomized clinical trials.
Thomas Gärtner, Juliana Schneider, Bert Arnrich, Stefan Konigorski   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Use of KAOS in operational digital forensic investigations [PDF]

, 2013
. This paper focuses on the operations involved in the digital forensic process using the requirements engineering framework KAOS. The idea is to enforce the claim that a requirements engineering approach to digital forensics produces reusable patterns ...
Benjamin Aziz, Blackwell, C., Aziz, Benjamin, Clive Blackwell   +3 more
core  

Human Digital Healthcare Engineering for Enhancing the Health and Well-Being of Seafarers and Offshore Workers: A Comprehensive Review [PDF]

With over 50,000 merchant vessels and nearly two million seafarers operating globally, more than 12,000 maritime incidents in the past decade underscore the urgent need for proactive safety measures to ensure the structural integrity of aging ships and ...
Jeom-Kee Paik, Meng-Xuan Cui, Kun-Hou He, Fang Wang   +3 more
core   +1 more source

A Digital Engineering Framework for Piston Pin Bearings via Multi-Physics Thermo-Elasto-Hydrodynamic Modeling

Systems
The piston pin operates under severe mechanical and thermal conditions, making accurate lubrication prediction essential for engine durability. This study presents a comprehensive digital engineering framework for piston pin bearings, built upon a fully ...
Zhiyuan Shu, Tian Tian
doaj   +1 more source