Results 61 to 70 of about 978,255 (310)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Managing Design Variants in Formula Student Race Cars: A Digital Engineering Approach Across Multiple Teams

Vehicles
Increasing product complexity, shorter development cycles and cross-domain integration demands pose significant challenges for modern race car engineering teams.
Julian Borowski, Hinrich Emsmann, Jannis Kneule, Rico Ruess, Stephan Rudolph   +4 more
doaj   +1 more source

Industry Based Adaptive Educational Programs

Высшее образование в России, 2019
The aim of this work is to summarize the experience in the development and implementation of industry-oriented educational programs in the field of digital engineering in the educational process.The article presents an example of the interaction of the ...
M. G. Ganchenkova, O. V. Boyko
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

System Analysis of Environmental Effects: A Case of Sustainable Development in the Russian Economy Based on Digital Engineering

Systems
The conceptual foundation of this research is the idea of convergence between such development directions of modern production systems as digital design tools and sustainable development.
Farida F. Galimulina, Aleksei I. Shinkevich, Naira V. Barsegyan   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Collaborative Reverse Engineering Design Experiment Using PLM Solutions [PDF]

, 2011
The current climate of economic competition forces businesses to adapt to the expectations of their customers. To achieve this, in spite of the increasing complexity of mechanical systems, it becomes necessary, amongst other things, to reduce design time.
AOUSSAT, Améziane, VERON, Philippe, SEGONDS, Frederic, MARANZANA, Nicolas   +3 more
core  

Virtual Reality Models and Digital Engineering Solutions for Technology Transfer

Applied Computer Systems, 2015
Effective applied research is based on close collaboration between research and industry, which taking the findings of basic research on customer demands as its starting point, creates a new means for developing and marketing innovative products. What is
Schumann Marco, Leye Stefan, Popov Artyom   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source