Results 61 to 70 of about 320,751 (246)

Decision Analysis Data Model for Digital Engineering Decision Management

Systems
Decision management is the systems engineering life cycle process for making program/system decisions. The purpose of the decision management process is: “…to provide a structured, analytical framework for objectively identifying, characterizing and ...
Gregory S. Parnell, C. Robert Kenley, Devon Clark, Jared Smith, Frank Salvatore, Chiemeke Nwobodo, Sheena Davis   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Digital Engineering in Diffractive Optics for Precision Laser Processing

Photonics
This article focuses on the application of digital engineering in diffractive optics for precision laser material processing. It examines methods for the development of diffractive optical elements (DOEs) and adaptive management approaches that enhance ...
Serguei P. Murzin
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Managing Design Variants in Formula Student Race Cars: A Digital Engineering Approach Across Multiple Teams

Vehicles
Increasing product complexity, shorter development cycles and cross-domain integration demands pose significant challenges for modern race car engineering teams.
Julian Borowski, Hinrich Emsmann, Jannis Kneule, Rico Ruess, Stephan Rudolph   +4 more
doaj   +1 more source

Construction and Application of Digital Asset Platform for Hydropower Engineering

Renmin Zhujiang, 2022
The development of informatization and digitization of hydropower engineering is exposed to problems such as inconsistent data standards,uneven data quality,scattered data storage,weak correlation between data,and difficult data sharing.By referring to ...
JIA Yuhao
doaj  

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

System Analysis of Environmental Effects: A Case of Sustainable Development in the Russian Economy Based on Digital Engineering

Systems
The conceptual foundation of this research is the idea of convergence between such development directions of modern production systems as digital design tools and sustainable development.
Farida F. Galimulina, Aleksei I. Shinkevich, Naira V. Barsegyan   +2 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source