Results 61 to 70 of about 497,329 (259)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A corpus and a modular infrastructure for the empirical study of (an)notated music

Scientific Data
The present corpus is the outcome of a long-term collaborative effort to produce analytically annotated music scores suitable for the computer-assisted study of European compositions since 1600.
Johannes Hentschel, Yannis Rammos, Markus Neuwirth, Martin Rohrmeier   +3 more
doaj   +1 more source

ARletta. Open-Source Handwritten Text Recognition Models for Historic Dutch

Journal of Open Humanities Data
We release ARletta, a series of open-source models for the automated transcription of historic Dutch-language handwritten sources, which has remained a desideratum in the scholarly community until now.
Lith Lefranc, Ilja Van Damme, Thibault Clérice, Mike Kestemont   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Who's afraid of Patterns?: The Particular versus the Universal and the Meaning of Humanities 3.0

BMGN: Low Countries Historical Review, 2013
The advent of Digital Humanities has enabled scholars to identify previously unknown patterns in the arts and letters; but the notion of pattern has also been subject to debate.
Rens Bod
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Coordinated Europeanization of the Comics Industry through Distribution: The Politics of the Global Journey of Astérix and Tintin through the Strategic Distribution of their Magazines and Contents in the 1960s

On_Culture, 2019
Researchers have usually focused on the Tintin and Astérix series’ global book diffusion through translation. However, little has been discussed about the distribution policies of the comics magazine format, a key factor in the development of European ...
Jessica Burton
doaj  

‘A Digital Archive of Ireland’s Ordnance Survey’: Connecting Collections for Nineteenth-Century Ireland

Journal of Open Humanities Data
A three-year digital humanities research project, a collaboration between Queen’s University Belfast (QUB), the University of Limerick (UL) and the Digital Repository of Ireland (DRI), gathered historic Irish Ordnance Survey (OS) maps and texts into a ...
Lisa Griffith, Zenobie S. Garrett, Stuart Kenny, Keith D. Lilley, Catherine Porter   +4 more
doaj   +1 more source