Results 51 to 60 of about 23,235 (228)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Keynote 3

Pakistan Journal of Information Management & Libraries, 2016
This paper addresses the relationship between Digital Libraries (DL) and Digital Humanities (DH) with a special focus on global access to knowledge. An overview DL & DH and their interconnections are described.
Widad El Hadi
doaj  

Descriptive markup languages and the development of digital humanities

Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2012
The paper discusses the role of descriptive markup languages in the development of digital humanities, a new research discipline that is part of social sciences and humanities, which focuses on the use of computers in research.
Boris Bosančić
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Lecture: Getting from here to there

MedieKultur: Journal of Media and Communication Research, 2014
Based on his keynote lecture at the international conference on Digital Humanities at Aalborg University in April 2014, John Naughton refl ects on being an engineer in a Humanities research institute that is currently seeking to adapt to the digital ...
John Naughton
doaj   +3 more sources

A Digital 4D Information System on the World Scale: Research Challenges, Approaches, and Preliminary Results

Applied Sciences
Numerous digital media repositories have been set up during recent decades, each containing plenty of data about historic cityscapes. In contrast, digital 3D reconstructions of no longer extant cityscapes have so far almost solely been performed for ...
Sander Münster, Ferdinand Maiwald, Jonas Bruschke, Cindy Kröber, Ying Sun, Daniel Dworak, Dávid Komorowicz, Iqra Munir, Clemens Beck, Dora Luise Münster   +9 more
doaj   +1 more source

Corpus Linguistics and Digital Humanities. Intersecting Paths. A Case Study from Twitter

América Crítica, 2020
In this paper I aim at critically discussing the role of Corpus Linguistics within the field of Digital Humanities. I posit that the accessible and user-friendly tools of Corpus Linguistics are an optimal resource for scholars within the Humanities and ...
Angela Zottola
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

DIGITAL HUMANITIES IN HIGHER EDUCATION SYSTEM OF CANADA

Неперервна професійна освіта: теорія та практика, 2019
The urgency of the article is due to the increased impact of information and communication technologies on research in the field of socio-humanitarian cycle sciences, which led to the emergence of interdisciplinary direction of research and projects ...
Olena Voskoboinikova-Huzieva
doaj   +1 more source