Results 51 to 60 of about 30,122 (246)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Pakistan Journal of Information Management & Libraries, 2016 This paper addresses the relationship between Digital Libraries (DL) and Digital Humanities (DH) with a special focus on global access to knowledge. An overview DL & DH and their interconnections are described.
Widad El Hadi
doaj
Applied SciencesNumerous digital media repositories have been set up during recent decades, each containing plenty of data about historic cityscapes. In contrast, digital 3D reconstructions of no longer extant cityscapes have so far almost solely been performed for ...
Sander Münster +9 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
DIGITAL HUMANITIES IN HIGHER EDUCATION SYSTEM OF CANADA
Неперервна професійна освіта: теорія та практика, 2019 The urgency of the article is due to the increased impact of information and communication technologies on research in the field of socio-humanitarian cycle sciences, which led to the emergence of interdisciplinary direction of research and projects ...
Olena Voskoboinikova-Huzieva
doaj +1 more source
Sustaining Digital Humanities Collections: Challenges and Community-Centred Strategies
International Journal of Digital Curation, 2020 Since the advent of digital scholarship in the humanities, decades of extensive, distributed scholarly efforts have produced a digital scholarly record that is increasingly scattered, heterogeneous, and independent of curatorial institutions.
Katrina Simone Fenlon
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Interdisciplinary Collaboration in Studying Newspaper Materiality
Digital Humanities in the Nordic and Baltic Countries Publications, 2019 This paper presents a collaboration between computer scientists, linguists and historians studying the material aspects of newspapers and developing a tool for that purpose.
Eetu Mäkelä +5 more
doaj +1 more source