Results 51 to 60 of about 335,808 (309)

Identifying Factors Influencing Digital Reading Behavior: A Meta-Synthesis Study [PDF]

کتابداری و اطلاع‌رسانی
Objective: With the expansion of digital technologies, the methods of reading and user interaction with information sources have changed. Digital reading, as one of the most significant consequences of this transformation, has brought new opportunities ...
Sara Nildarar, Mansoor Koohi Rostami
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Education and Technology [PDF]

Journal of Systemics, Cybernetics and Informatics, 2022
The aim of this paper is to explore what we know about the difficulties from comprehension of digital texts in comparison with traditional texts with a particular focus on new readers.
Rossella Marzullo
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Family visits to libraries and bookshops: observations and implications for digital libraries

, 2014
This paper explores how families select books for leisure reading. We recruited 17 families (adults and children) for this study, and spent time with each in both bookshops and public libraries.
Sally Jo Cunningham, Vanderschantz, Nicholas, Hinze, Annika, Nicholas Vanderschantz, Timpany, Claire, Cunningham, Sally Jo, Annika Hinze, Claire Timpany   +7 more
core   +1 more source

Multimodal Analyses and Visual Models for Qualitatively Understanding Digital Reading and Writing Processes

Education Sciences
As technology continues to shape how students read and write, digital literacy practices have become increasingly multimodal and complex—posing new challenges for researchers seeking to understand these processes in authentic educational settings.
Amanda Yoshiko Shimizu, Michael Havazelet, Blaine E. Smith, Amanda P. Goodwin   +3 more
doaj   +1 more source

Lectura textului digital şi profilul noului cititor [PDF]

Revista de Istorie și Teorie Literară
The paper aims to identify the recurring elements ordering current theories of digital reading and to trace the profile of a new reader. The meanings of reading are synonymous here with deep reading, not hyperreading, and by digital texts we mean digital
Daniela Petroşel
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Reading and the digital revolution [PDF]

, 2007
Response to Maryanne Wolf's article in which she pondered the digital revolution’s potential to ‘unravel 5000 years of learning’ in relation to reading ('Will kids lose skill to think?', HSun, 20/10/07)
Henderson, Robyn
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source