Results 51 to 60 of about 212,627 (263)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Éléments de validation d’une échelle de mesure des connaissances métacognitives liées à la lecture numérique

Mesure et Évaluation en Éducation, 2022
Cette étude vise à identifier des traces de validité d’une échelle de mesure des connaissances métacognitives de la lecture numérique inédite, développée pour le PISA 2018 et, plus particulièrement, à établir si cette échelle mesure des connaissances ...
Dominique Lafontaine, Nina Jude, Johanna Leck   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Examining College Students' Reading Behaviors and Needs for Ebook Readers [PDF]

Journal of Library and Information Studies, 2012
This study investigates college students' reading behaviors and attitudes toward print and electronic carriers of books. With the prosperity and variety of ebook readers currently, it is important to understand the genuine needs of the users to better ...
Wei-Jane Lin, Hsiu-Ping Yueh
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Effect of Mobile Social Networking on the Reading Habit of the Student Teachers of Frahangian University in South Khorasan Province [PDF]

تحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی, 2021
Purpose: Since today the use of mobile phones is extremely widespread, and individuals with different age groups and social classes devote a considerable amount of time to using these social networks, training the use of these networks can provide a ...
Leili Seifi, Mohsen Ayati
doaj  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Fostering Autonomy through Digital Reading: Students’ Evaluation of the ReadyRead Application

Jurnal Pendidikan Humaniora, 2020
: ReadyRead is an Android-based application which provides several features for scaffolding reading comprehension practice. It is the product of Design-Based Research.
Rulli Putri Maulidia, Fransisca Maria Ivone, Anik Nunuk Wulyani   +2 more
doaj  

Identifying Factors Influencing Digital Reading Behavior: A Meta-Synthesis Study [PDF]

کتابداری و اطلاع‌رسانی
Objective: With the expansion of digital technologies, the methods of reading and user interaction with information sources have changed. Digital reading, as one of the most significant consequences of this transformation, has brought new opportunities ...
Sara Nildarar, Mansoor Koohi Rostami
doaj   +1 more source