Results 251 to 260 of about 1,540,423 (323)

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Evaluating the knowledge and usage of digital health tools in rural Oyo State, Nigeria: a cross-sectional study of healthcare professionals and residents. [PDF]

BMC Public Health
Okeke EB, Forman D, Taylor E, Hyde E, Parente F, Kanmodi KK, Wordsworth S.   +6 more
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Correction to "Mixed-Methods Evaluation of the Expanded Implementation of Supported Education Within Community Youth Mental Health Services". [PDF]

Early Interv Psychiatry
europepmc   +1 more source

Improving patients' satisfaction through service digitalization: a cross-sectional study based on the theory of psychological empowerment. [PDF]

BMC Health Serv Res
Zhou GS, Shi SH, Qian QR, Zheng QY.
europepmc   +1 more source

Exploring Pharmacist's Attitude, Perception, Concern, and Practice Regarding Artificial Intelligence in Pharmacy Practice: Cross Sectional Quantitative Analysis. [PDF]

Hosp Pharm
Urooj S, Faheem M.
europepmc   +1 more source

Online Health Information-Seeking Among Older Adults and Predictors of Use, Motivations, and Barriers in the Context of Healthy Aging: Cross-Sectional Study. [PDF]

Online J Public Health Inform
Bachofner Y, Seifert A, Sepahniya S, Fabian C.   +3 more
europepmc   +1 more source

Improving access to healthcare services for people experiencing homelessness: evidence from a scoping review of interventions. [PDF]

Health Justice
Meda F, Oprea N, Buongiorno Sottoriva C.
europepmc   +1 more source

Methodological Considerations in Evaluating Mental Health Apps: Ensuring Reliability and Patient Safety.

JMIR Mhealth Uhealth
Balakrishna H.
europepmc   +1 more source

Transforming Caring for Dependent Older People: A New Approach for Integrated Socio-Healthcare. [PDF]

Scand J Caring Sci
Porcel-Gálvez AM, Allande-Cussó R, Lima-Serrano M.   +2 more
europepmc   +1 more source