Results 41 to 50 of about 205,289 (220)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Model for assessing the maturity level of digital transformation in higher education institutions: a theoretical-methodological approach

Frontiers in Education
In these times of increasing digitization and process automation, digital transformation (DT) has become a determining factor for continuous improvement and competitiveness in organizations in all areas.
Jessie Bravo-Jaico, Roger Alarcón, Carlos Valdivia, Nilton Germán, Janet Aquino, Oscar Serquén, Laurita Guevara, Armando Moreno Heredia   +7 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Advancing cell therapy manufacturing: an image-based solution for accurate confluency estimation

Frontiers in Bioengineering and Biotechnology
Cell therapies represent a transformative approach for treating diseases resistant to conventional therapies, yet their development and manufacturing face significant hurdles within the biopharmaceutical sector.
John Mason, Martin Kraft, Jakob Hueckels, Hao Wei, Konstantinos Spetsieris   +4 more
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Assessments Used for Summative Purposes during Internal Medicine Specialist Training: A Rapid Review

Education Sciences, 2023
Assessments used for summative purposes of patient-facing clinical competency in specialist internal medicine training are high-stakes, both to doctors in training, as it is a prerequisite for qualification, as well as their community of prospective ...
Scott Patterson, Louise Shaw, Michelle M Rank, Brett Vaughan   +3 more
doaj   +1 more source

Digital Transformation of the Ukrainian Economy: Digitization and Transformation of Business Models [PDF]

SHS Web of Conferences, 2019
The studies are devoted to the transformational processes associated with digitalization, which takes place in the Ukrainian economy. Economic development is impossible without widespread introduction and full use of the digital technologies. The rate of digital innovation is growing every year.
Anastasiia Bozhok, Olha Levchenko, Viktoriia Yanovska, Viktoriia Tvoronovych   +3 more
openaire   +3 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Analysis of the current status and future vision of innovation in a tertiary hospital in Catalonia: a cross-sectional study

BMC Health Services Research
Background Innovation in healthcare is a complex process involving the creation or modification of products, services, or processes, and their successful implementation in clinical settings. University Hospital Germans Trias i Pujol (HUGTP) implemented a
Mireia Cano, Eloi Querol Carranza, Gerard Albreda, Laura Ricou, Oriol Estrada, Daniel Moreno-Martinez   +5 more
doaj   +1 more source

Systematic review: Decentralised health information systems implementation in sub-Saharan Africa

The Journal for Transdisciplinary Research in Southern Africa, 2022
Globally the health space is being revolutionised by rapid digital transformation to support care activities, promote healthier lifestyles and ensure informed decision making to improve service delivery. However, many health systems in sub-Saharan Africa
Oluwamayowa O. Ogundaini, Mourine S. Achieng   +1 more
doaj   +1 more source