Results 71 to 80 of about 337,845 (323)

Digital Twins along the product lifecycle: A systematic literature review of applications in manufacturing [version 2; peer review: 2 approved, 2 approved with reservations]

Digital Twin
Background The evolution of product expectations in the era of mass personalization implies an improvement and a better control of individualized creation and production processes throughout the product lifecycle.
Frédérique Mayer, Guillaume Pronost, Laurent Dupont, Mauricio Camargo   +3 more
doaj   +1 more source

Digital twin-driven complexity management in intelligent manufacturing [version 1; peer review: 2 approved]

Digital Twin, 2021
Complexity management is one of the most crucial and challenging issues in manufacturing. As an emerging technology, digital twin provides an innovative approach to manage complexity in a more autonomous, analytical and comprehensive manner.
Ang Liu, Yuchen Wang, Xingzhi Wang, Fei Tao   +3 more
doaj   +1 more source

Reinforcement Learning for UAV Attitude Control [PDF]

, 2018
Autopilot systems are typically composed of an "inner loop" providing stability and control, while an "outer loop" is responsible for mission-level objectives, e.g. way-point navigation.
Bestavros, Azer, Koch, William, Mancuso, Renato, West, Richard   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Digital Twin

, 2023
Denne masteroppgaven har som mål å bidra til å utvikle en Digital Tvilling som i samarbeid med industrielle samarbeidspartnere er på vei. Oppgaven produserer pålitelige eksperimentelle caser som lager et solid fundament for framtidig bruk i en Digital Tvilling.
Ranjan Ganguli, Sondipon Adhikari, Souvik Chakraborty, Mrittika Ganguli   +3 more
openaire   +3 more sources

Mapping an ancient historian in a digital age: the Herodotus Encoded Space-Text-Image Archive (HESTIA) [PDF]

, 2010
HESTIA (the Herodotus Encoded Space-Text-Imaging Archive) employs the latest digital technology to develop an innovative methodology to the study of spatial data in Herodotus' Histories.
Barker, Elton, Bouzarovski, Stefan, Isaksen, Leif, Pelling, Chris   +3 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

MicroMap: a network visualisation resource for human microbiome metabolism

npj Biofilms and Microbiomes
The human microbiome critically influences metabolism and thereby our health. Constraint-based reconstruction and analysis (COBRA) is a proven framework for generating mechanism-derived hypotheses along the nutrition-host-microbiome-disease axis. However,
Cyrille C. Thinnes, Renee Waschkowitz, Eoghan Courtney, Eoghan Culligan, Katie Fahy, Ruby A. M. Ferrazza, Ciara Ferris, Angeline Lagali, Rebecca Lane, Colm Maye, Olivia Murphy, David Noone, Saoirse Ryan, Mihaela Bet, Maria C. Corr, Hannah Cummins, David Hackett, Ellen Healy, Nina Kulczycka, Niall Lang, Luke Madden, Lynne McHugh, Ivana Pyne, Ciara Varley, Niamh Harkin, Ronan Meade, Grace O’Donnell, Bram Nap, Filippo Martinelli, Almut Heinken, Ines Thiele   +30 more
doaj   +1 more source

Human-Machine Interface for Remote Training of Robot Tasks

, 2018
Regardless of their industrial or research application, the streamlining of robot operations is limited by the proximity of experienced users to the actual hardware.
Boukas, Evangelos, Buzatoiu, Roxana, Nalpantidis, Lazaros, Polydoros, Athanasios, Spranger, Jordi   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source