Clinical Use of Digitalis Glycosides
Cardiology, 1985 Digitalis glycosides continue to place high on the list of prescribed drugs. Digoxin is 8th on prescriptions written in the United States in 1980, digitoxin 16th, and digitalis leaf 23rd. There is little doubt that most physicians continue to believe these drugs are useful.
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Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta [PDF]
, 2013 Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation of the cardiac drug digoxin by the
Balskus, Emily Patricia +5 more
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Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. [PDF]
, 2019 The term "inotrope" is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock.
Adams, KF +7 more
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Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts [PDF]
, 2017 Objective: The aim was to determine whether failing human hearts have increased sensitivity to the inotropic and toxic effects of ouabain, and to examine alterations in Na/K-ATPase that might explain the observed higher ouabain sensitivity.
Gradoux, Nathalie +7 more
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Does Digoxin Provide Additional Hemodynamic and Autonomic Benefit at Higher Doses in Patients With Mild to Moderate Heart Failure and Normal Sinus Rhythm? [PDF]
, 1997 Objectives. This study sought to examine the hemodynamic and autonomic dose response to digoxin.Background. Previous studies have demonstrated an increase in contractility and heart rate variability with digitalis preparations.
Eichhorn, Eric J +6 more
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Biotecnología Vegetal, 2008 Digitalis purpurea L. produces cardiatonic glycosides such as digoxin and digitoxin, which are widely used for congestive heart failure. Genomic studies in this specie are limited because there is not an efficient genetic transformation system.
Borys Chong-Pérez +5 more
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The Chemical Estimation of Digitalis and Strophanthus Glycosides
Journal of Pharmacy and Pharmacology, 1949 Abstract Certain glycosides of plant origin possess valuable cardiotonic properties. The Families Scrophulariaceae and Apocynaceae are the plant orders which contain most members furnishing drugs of therapeutic value. If in this connection the toad poisons are included, the heart-active substances from a chemical viewpoint may be ...
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Iraqi Journal of Pharmaceutical Sciences, 2017 The present study was performed using the tissue culture technique , where by roots formation was stimulated shoot tips of Digitalis purpurea L plant using auxins in this study ,shoot tips (1cm length ) were excised from sterilized seedlings of ...
Zeinab J. Aawad, Ekbal H. Al- Khateeb
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The Cardiac Glycosides Digitoxin, Digoxin and Ouabain Induce a Potent Inhibition of Glycolysis in Lung Cancer Cells [PDF]
, 2013 Cardiac glycosides are promising anticancer drugs. We have recently shown that the cardiac glycosides digitoxin, digoxin and ouabain induce selective killing of lung cancer cells, and that the cytotoxicity of digitoxin against these cells occurs at ...
Burgos Morón, Estefanía +2 more
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Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts [PDF]
, 2008 Objectives: To evaluate concentration-dependent effects of total extract of Rusta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.
Golalipour, M.J. +4 more
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