Probing the interaction of lysozyme with cardiac glycoside digitoxin: experimental and in silico analyses [PDF]
Frontiers in Molecular Biosciences, 2023 Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali +3 more
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Foliar application of esculin and digitoxin improve the yield quality of salt-stressed flax by improving the antioxidant defense system [PDF]
BMC Plant BiologyBackground Secondary metabolites of several plants, including esculin and digitoxin, which are cardiac glycosides, were previously employed for their therapeutic effects.
Hemmat I. Khattab +4 more
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Ueber Digitoxin und Gitalin [PDF]
Archiv der Pharmazie, 1913 n ...
H. Kiliani
semanticscholar +6 more sources
Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach [PDF]
Cancer MedicineBackground and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (
Wenjie Qin +8 more
doaj +3 more sources
Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation [PDF]
Molecules, 2016 Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC.
Yi-Ze Zhang +11 more
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Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods [PDF]
Scientific ReportsThe solubility of medications in supercritical solvent is the most important factor that can be determined via appropriate computational tools. This work explores the modeling of digitoxin solubility as the case study in supercritical CO2 and solvent ...
Hadil Faris Alotaibi +8 more
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The in vivo effect of digitoxin on rat heart phosphatides*
Journal of Lipid Research, 1961 Digitoxin was shown to increase the specific activity of heart ventricle phosphatides in rats receiving simultaneously radioactive orthophosphate and digitoxin as compared to control rats not receiving digitoxin.
G.V. Marinetti, K. Temple, Elmer Stotz
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Interspecies Differences in Cytomegalovirus Inhibition by Cardiac Glycosides—A Unique Role of the Alpha3 Isoform of the Na+/K+-ATPase Pump [PDF]
VirusesCardiac glycosides (CGs), historically used to treat heart failure and arrhythmias, bind to the α subunit of the Na+/K+-ATPase pump and inhibit its activity. Their anticancer and antiviral activities are of interest.
Hong Mei +9 more
doaj +2 more sources
Digitoxin medication and cancer; case control and internal dose-response studies [PDF]
BMC Cancer, 2001 Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Methods Computer
Spigset Olav +3 more
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Digitoxin metabolism by rat liver microsomes. [PDF]
, 1975 Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs. Objective: To review the impact of malnutrition on hospital LOS and costs in Europe.
Benthe, H.F. +2 more
core +3 more sources