Results 1 to 10 of about 11,104 (231)

Probing the interaction of lysozyme with cardiac glycoside digitoxin: experimental and in silico analyses [PDF]

Frontiers in Molecular Biosciences, 2023
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali, Hamad A. Al-Lohedan, Rittik Bhati, Jayaraman Muthukumaran   +3 more
doaj   +3 more sources

Foliar application of esculin and digitoxin improve the yield quality of salt-stressed flax by improving the antioxidant defense system [PDF]

BMC Plant Biology
Background Secondary metabolites of several plants, including esculin and digitoxin, which are cardiac glycosides, were previously employed for their therapeutic effects.
Hemmat I. Khattab, Mervat Sh. Sadak, Mona G. Dawood, Fatma M. A. Elkady, Nesma M. Helal   +4 more
doaj   +3 more sources

Inhibitory Effects of Digoxin and Digitoxin on Cell Growth in Human Ovarian Cancer Cell Line SKOV-3

Integrative Cancer Therapies, 2021
Background: Cardiac glycosides (CGs) possess a chemical structure similar to steroids, and are inhibitors of the sodium potassium pump. An anti-tumor effect of CGs in breast and prostate cancers has been reported, but the effect of CGs on ovarian cancer ...
Jou-Chun Chou, Jie-Hau Li, Chih-Chieh Chen, Chien-Wei Chen, Ho Lin, Paulus S. Wang   +5 more
doaj   +2 more sources

Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial. [PDF]

Clin Res Cardiol, 2023
The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial. In DIGIT-HF, digitoxin
Bavendiek U, Großhennig A, Schwab J, Berliner D, Liu X, Maier L, Gaspar T, Rieth A, Philipp S, Hambrecht R, Westenfeld R, Münzel T, Winkler S, Hülsmann M, Westermann D, Zdravkovic M, Lichtinghagen R, von der Leyen H, Zimmermann S, Veltmann C, Böhm M, Störk S, Koch A, Bauersachs J.   +23 more
europepmc   +2 more sources

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis.
Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Matthew D. Wilkerson, Xijun Zhang, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard, Harvey B. Pollard   +18 more
doaj   +2 more sources

Interspecies Differences in Cytomegalovirus Inhibition by Cardiac Glycosides—A Unique Role of the Alpha3 Isoform of the Na⁺/K⁺-ATPase Pump [PDF]

Viruses
Cardiac glycosides (CGs), historically used to treat heart failure and arrhythmias, bind to the α subunit of the Na+/K+-ATPase pump and inhibit its activity. Their anticancer and antiviral activities are of interest.
Hong Mei, Hongyi Cai, Fengjie Liu, Rajkumar Venkatadri, Halli E. Miller, Angela J. Mathison, Hua-Yu Leo Wang, Simone C. Silva, George A. O’Doherty, Ravit Arav-Boger   +9 more
doaj   +2 more sources

Digitoxin and its analogs as novel cancer therapeutics

Experimental Hematology & Oncology, 2012
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile.
Elbaz Hosam A, Stueckle Todd A, Tse William, Rojanasakul Yon, Dinu Cerasela   +4 more
doaj   +2 more sources

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation

Molecules, 2016
Non-small-cell lung cancer (NSCLC) dominates over 85% of all lung cancer cases. Epidermal growth factor receptor (EGFR) activating mutation is a common situation in NSCLC.
Yi-Ze Zhang, Xi Chen, Xing-Xing Fan, Jian-Xing He, Jun Huang, Da-Kai Xiao, Yan-Ling Zhou, Sen-You Zheng, Jia-Hui Xu, Xiao-Jun Yao, Liang Liu, Elaine Lai-Han Leung   +11 more
doaj   +2 more sources

Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor–positive and triple-negative breast cancer cells

Tumor Biology, 2017
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer   +6 more
doaj   +2 more sources

Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods [PDF]

Scientific Reports
The solubility of medications in supercritical solvent is the most important factor that can be determined via appropriate computational tools. This work explores the modeling of digitoxin solubility as the case study in supercritical CO2 and solvent ...
Hadil Faris Alotaibi, Waqed H. Hassan, Ahmed Kateb Jumaah Al-Nussairi, Narinderjit Singh Sawaran Singh, Ahmed Salah Al-Shati, M. M. Rekha, Subhashree Ray, Aashna Sinha, Gunjan Garg   +8 more
doaj   +2 more sources