Probing the interaction of lysozyme with cardiac glycoside digitoxin: experimental and in silico analyses [PDF]
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali+3 more
doaj +4 more sources
Foliar application of esculin and digitoxin improve the yield quality of salt-stressed flax by improving the antioxidant defense system [PDF]
Background Secondary metabolites of several plants, including esculin and digitoxin, which are cardiac glycosides, were previously employed for their therapeutic effects.
Hemmat I. Khattab+4 more
doaj +3 more sources
Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach [PDF]
Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (
Wenjie Qin+8 more
doaj +3 more sources
Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma [PDF]
RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their potential role
Cunjie Chang+31 more
doaj +3 more sources
Digitoxin medication and cancer; case control and internal dose-response studies [PDF]
Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Methods Computer
Spigset Olav+3 more
doaj +5 more sources
Interspecies Differences in Cytomegalovirus Inhibition by Cardiac Glycosides—A Unique Role of the Alpha3 Isoform of the Na+/K+-ATPase Pump [PDF]
Cardiac glycosides (CGs), historically used to treat heart failure and arrhythmias, bind to the α subunit of the Na+/K+-ATPase pump and inhibit its activity. Their anticancer and antiviral activities are of interest.
Hong Mei+9 more
doaj +2 more sources
The DIGIT-HF trial: Key amendments of study design. [PDF]
European Journal of Heart Failure, Volume 27, Issue 3, Page 606-608, March 2025.
Bavendiek U+30 more
europepmc +2 more sources
Transforming Growth Factor-β Pathway: Biological Functions and Therapeutic Targets. [PDF]
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Mekky RH+9 more
europepmc +2 more sources
The in vivo effect of digitoxin on rat heart phosphatides*
Digitoxin was shown to increase the specific activity of heart ventricle phosphatides in rats receiving simultaneously radioactive orthophosphate and digitoxin as compared to control rats not receiving digitoxin.
G.V. Marinetti, K. Temple, Elmer Stotz
doaj +2 more sources
Ueber Digitoxin und Gitalin [PDF]
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H. Kiliani
openaire +5 more sources