Results 1 to 10 of about 2,840 (150)

Probing the interaction of lysozyme with cardiac glycoside digitoxin: experimental and in silico analyses [PDF]

Frontiers in Molecular Biosciences, 2023
Digitoxin is a cardiac glycoside used to treat heart failure and heart arrhythmia. However, its therapeutic concentration range is very narrow. High doses of digitoxin are associated with severe side effects; therefore, it is necessary to develop the ...
Mohd Sajid Ali, Hamad A. Al-Lohedan, Rittik Bhati, Jayaraman Muthukumaran   +3 more
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Digitoxin-induced apoptosis in ovarian granulosa cells disrupts follicular development and impairs reproductive performance [PDF]

Journal of Ovarian Research
Background Digitoxin, a cardiac glycoside from Digitalis spp., is clinically employed for heart failure and atrial fibrillation, and yet its reproductive toxicity is not well understood.
Yao Jiang, Meng Lv, YuYang Zhong, Yonghua Shi, Jing Wang, Xiaolong Yuan, Bin Ma   +6 more
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Interspecies Differences in Cytomegalovirus Inhibition by Cardiac Glycosides—A Unique Role of the Alpha3 Isoform of the Na⁺/K⁺-ATPase Pump [PDF]

Viruses
Cardiac glycosides (CGs), historically used to treat heart failure and arrhythmias, bind to the α subunit of the Na+/K+-ATPase pump and inhibit its activity. Their anticancer and antiviral activities are of interest.
Hong Mei, Hongyi Cai, Fengjie Liu, Rajkumar Venkatadri, Halli E. Miller, Angela J. Mathison, Hua-Yu Leo Wang, Simone C. Silva, George A. O’Doherty, Ravit Arav-Boger   +9 more
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Foliar application of esculin and digitoxin improve the yield quality of salt-stressed flax by improving the antioxidant defense system [PDF]

BMC Plant Biology
Background Secondary metabolites of several plants, including esculin and digitoxin, which are cardiac glycosides, were previously employed for their therapeutic effects.
Hemmat I. Khattab, Mervat Sh. Sadak, Mona G. Dawood, Fatma M. A. Elkady, Nesma M. Helal   +4 more
doaj   +2 more sources

Computational machine learning estimation of digitoxin solubility in supercritical solvent at different temperatures utilizing ensemble methods [PDF]

Scientific Reports
The solubility of medications in supercritical solvent is the most important factor that can be determined via appropriate computational tools. This work explores the modeling of digitoxin solubility as the case study in supercritical CO2 and solvent ...
Hadil Faris Alotaibi, Waqed H. Hassan, Ahmed Kateb Jumaah Al-Nussairi, Narinderjit Singh Sawaran Singh, Ahmed Salah Al-Shati, M. M. Rekha, Subhashree Ray, Aashna Sinha, Gunjan Garg   +8 more
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Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach [PDF]

Cancer Medicine
Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (
Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang   +8 more
doaj   +2 more sources

A 7,000-year-old multi-component arrow poison from Kruger Cave, South Africa [PDF]

iScience
Summary: We present the results of a GC-MS and UHPLC-MS analysis of residue recovered from the marrow cavity of a 7,000-year-old bovid femur from Kruger Cave, South Africa.
Justin Bradfield, Ian A. Dubery, Paul A. Steenkamp   +2 more
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Bioactivity of Cyperus amuricus extracts against hepatocellular carcinoma and molecular docking analysis targeting the PI3K/AKT/mTOR pathway. [PDF]

PLoS ONE
Cyperus amuricus (Cyperaceae) has exhibited potential anticancer activity against hepatocellular carcinoma (HCC), yet its molecular mechanisms and phytoconstituent interactions with oncogenic pathways remain underexplored.
Thanh Luan Nguyen, Thanh Khoi Tu, Thien-Vy Phan, Chanh M Nguyen, Khoa D Nguyen, Minh Quan Pham, Hai Ha Pham Thi   +6 more
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Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma [PDF]

Advanced Science
RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their potential role
Cunjie Chang, Lina Li, Ling Su, Fan Yang, Quanxiu Zha, Mengqing Sun, Lin Tao, Menglan Wang, Kangli Song, Liangyu Jiang, Haojin Gao, Yexin Liang, Chao Xu, Caiyu Yong, Minmin Wang, Jiacheng Huang, Jing Liu, Weiwei Jin, Wenyuan Lv, Heng Dong, Qian Li, Fangtian Bu, Shuanghong Yan, Haoxiang Qi, Shujuan Zhao, Yingshuang Zhu, Yu Wang, Junping Shi, Yiting Qiao, Jian Xu, Benoit Chabot, Jianxiang Chen   +31 more
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Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein [PDF]

Scientific Reports
SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, ENaC, the ...
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Ognoon Mungunsukh, Qingfeng Yang, Nathan I. Walton, Bette S. Pollard, Sara Khanal, Shannon Hentschel, Catalina Florez, Andrew S. Herbert, Harvey B. Pollard   +11 more
doaj   +2 more sources